Evaluation of sputum cultures in children with spinal Muscular atrophy
Copyright © 2023 Elsevier Ltd. All rights reserved..
BACKGROUND: Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder. Despite increased survival due to novel therapies, morbidity from respiratory complications still persists. We aim to describe these patients' sputum cultures as an expression of chronic infectious airway disease.
METHODS: Retrospective review of medical records of all children with SMA followed at the multidisciplinary respiratory neuromuscular clinic at Schneider Childrens' Medical Center of Israel over a 16-year period. Sputum cultures were obtained during routine visits or pulmonary exacerbations.
RESULTS: Sixty-one SMA patients, aged 1 month to 21 years, were included in this cohort. Of these, sputum cultures were collected from 41 patients. Overall, 288 sputum cultures were obtained, and 98 (34%) were negative for bacterial growth. For the first culture taken from each patient, 12 out of 41 (29%) were sterile. The most common bacteria were pseudomonas aeruginosa (PSA) (38%) and staphylococcus aureus (19.6%). PSA was found in SMA type I patients more frequently than in type II patients (15/26 = 58% vs 4/13 = 31%, p < 0.001). PSA infection was positively associated with noninvasive ventilation, recurrent atelectasis, recurrent pneumonias, swallowing difficulties, but no significant association was found with cough assist machine usage. The incidence of positive cultures did not differ between those treated with Onasemnogene abeparvovec or Nusinersen compared to those without treatment, but the age of first PSA isolation was slightly older with Nusinersen treatment (p = 0.01).
CONCLUSIONS: Airway bacterial colonization is common in SMA type I patients and is not decreased by Onasemnogene abeparvovec or Nusinersen treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:209 |
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| Enthalten in: |
Respiratory medicine - 209(2023) vom: 01. Apr., Seite 107143 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Levine, Hagit [VerfasserIn] |
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| Links: |
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| Themen: |
Airway infection |
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| Anmerkungen: |
Date Completed 08.03.2023 Date Revised 28.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.rmed.2023.107143 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352742569 |
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| 520 | |a Copyright © 2023 Elsevier Ltd. All rights reserved. | ||
| 520 | |a BACKGROUND: Spinal Muscular Atrophy (SMA) is a severe neuromuscular disorder. Despite increased survival due to novel therapies, morbidity from respiratory complications still persists. We aim to describe these patients' sputum cultures as an expression of chronic infectious airway disease | ||
| 520 | |a METHODS: Retrospective review of medical records of all children with SMA followed at the multidisciplinary respiratory neuromuscular clinic at Schneider Childrens' Medical Center of Israel over a 16-year period. Sputum cultures were obtained during routine visits or pulmonary exacerbations | ||
| 520 | |a RESULTS: Sixty-one SMA patients, aged 1 month to 21 years, were included in this cohort. Of these, sputum cultures were collected from 41 patients. Overall, 288 sputum cultures were obtained, and 98 (34%) were negative for bacterial growth. For the first culture taken from each patient, 12 out of 41 (29%) were sterile. The most common bacteria were pseudomonas aeruginosa (PSA) (38%) and staphylococcus aureus (19.6%). PSA was found in SMA type I patients more frequently than in type II patients (15/26 = 58% vs 4/13 = 31%, p < 0.001). PSA infection was positively associated with noninvasive ventilation, recurrent atelectasis, recurrent pneumonias, swallowing difficulties, but no significant association was found with cough assist machine usage. The incidence of positive cultures did not differ between those treated with Onasemnogene abeparvovec or Nusinersen compared to those without treatment, but the age of first PSA isolation was slightly older with Nusinersen treatment (p = 0.01) | ||
| 520 | |a CONCLUSIONS: Airway bacterial colonization is common in SMA type I patients and is not decreased by Onasemnogene abeparvovec or Nusinersen treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Airway infection | |
| 650 | 4 | |a Chronic suppurative lung disease | |
| 650 | 4 | |a Spinal muscular atrophy | |
| 650 | 4 | |a Sputum culture | |
| 700 | 1 | |a Nevo, Yoram |e verfasserin |4 aut | |
| 700 | 1 | |a Katz, Julia |e verfasserin |4 aut | |
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| 700 | 1 | |a Chodick, Gabriel |e verfasserin |4 aut | |
| 700 | 1 | |a Mei-Zahav, Meir |e verfasserin |4 aut | |
| 700 | 1 | |a Stafler, Patrick |e verfasserin |4 aut | |
| 700 | 1 | |a Steuer, Guy |e verfasserin |4 aut | |
| 700 | 1 | |a Bar-On, Ophir |e verfasserin |4 aut | |
| 700 | 1 | |a Mantin, Hadas |e verfasserin |4 aut | |
| 700 | 1 | |a Prais, Dario |e verfasserin |4 aut | |
| 700 | 1 | |a Aharoni, Sharon |e verfasserin |4 aut | |
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