The current status of medical care for myotonic dystrophy type 1 in the national registry of Japan
© 2023 Wiley Periodicals LLC..
INTRODUCTION/AIMS: Myotonic dystrophy (DM) is a systemic disease with multiple organ complications, making the standardization of medical care a challenge. We analyzed data from Japan's national registry to clarify the current treatment patterns and demographic features of Japanese DM patients.
METHODS: Using the Japanese National Registry of Muscular Dystrophy (Remudy), we analyzed medical care practice for the multisystemic issues associated with adult DM type 1 patients, excluding congenital DM.
RESULTS: We included 809 patients with a median age of 44.2 years. Among these patients, 15.8% used ventilators; 31.7% met the index considered at risk for sudden death due to cardiac conduction defects (PR interval over 240 milliseconds or QRS duration over 120 milliseconds) and 2.8% had implanted cardiac devices. Medication for heart failure was prescribed to 9.6% of patients. Overall, 21.2% of patients had abnormal glucose metabolism, of whom 42.9% were treated with oral medications. Among the oral medications, dipeptidyl peptidase-4 inhibitors were the most common. Cancers were observed in 3.7% of the patients, and endometrial and breast cancers were dominant. Mexiletine was prescribed for myotonia in 1.9% of the patients, and only 1% of the patients received medication for daytime sleepiness.
DISCUSSION: This study shows difference in treatment patterns for DM1 in Japan compared with other countries, such as lower rates of use of implantable cardiac devices and higher rates of ventilator use. These data may be useful in discussions aimed at standardizing medical care for patients with DM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Muscle & nerve - 67(2023), 5 vom: 08. Mai, Seite 387-393 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yamauchi, Kosuke [VerfasserIn] |
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| Links: |
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| Themen: |
Adult |
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| Anmerkungen: |
Date Completed 18.04.2023 Date Revised 21.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/mus.27799 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352722746 |
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| 245 | 1 | 4 | |a The current status of medical care for myotonic dystrophy type 1 in the national registry of Japan |
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| 500 | |a Date Revised 21.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Wiley Periodicals LLC. | ||
| 520 | |a INTRODUCTION/AIMS: Myotonic dystrophy (DM) is a systemic disease with multiple organ complications, making the standardization of medical care a challenge. We analyzed data from Japan's national registry to clarify the current treatment patterns and demographic features of Japanese DM patients | ||
| 520 | |a METHODS: Using the Japanese National Registry of Muscular Dystrophy (Remudy), we analyzed medical care practice for the multisystemic issues associated with adult DM type 1 patients, excluding congenital DM | ||
| 520 | |a RESULTS: We included 809 patients with a median age of 44.2 years. Among these patients, 15.8% used ventilators; 31.7% met the index considered at risk for sudden death due to cardiac conduction defects (PR interval over 240 milliseconds or QRS duration over 120 milliseconds) and 2.8% had implanted cardiac devices. Medication for heart failure was prescribed to 9.6% of patients. Overall, 21.2% of patients had abnormal glucose metabolism, of whom 42.9% were treated with oral medications. Among the oral medications, dipeptidyl peptidase-4 inhibitors were the most common. Cancers were observed in 3.7% of the patients, and endometrial and breast cancers were dominant. Mexiletine was prescribed for myotonia in 1.9% of the patients, and only 1% of the patients received medication for daytime sleepiness | ||
| 520 | |a DISCUSSION: This study shows difference in treatment patterns for DM1 in Japan compared with other countries, such as lower rates of use of implantable cardiac devices and higher rates of ventilator use. These data may be useful in discussions aimed at standardizing medical care for patients with DM | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a adult | |
| 650 | 4 | |a myotonic dystrophy | |
| 650 | 4 | |a registry | |
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| 700 | 1 | |a Matsumura, Tsuyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Takada, Hiroto |e verfasserin |4 aut | |
| 700 | 1 | |a Kuru, Satoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Michio |e verfasserin |4 aut | |
| 700 | 1 | |a Kubota, Tomoya |e verfasserin |4 aut | |
| 700 | 1 | |a Kimura, En |e verfasserin |4 aut | |
| 700 | 1 | |a Nakamura, Harumasa |e verfasserin |4 aut | |
| 700 | 1 | |a Takahashi, Masanori P |e verfasserin |4 aut | |
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