Multilamellar ceramide core-structured microvehicles with substantial skin barrier function recovery
This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone N-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:11 |
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| Enthalten in: |
Journal of materials chemistry. B - 11(2023), 10 vom: 08. März, Seite 2135-2144 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shin, Kyounghee [VerfasserIn] |
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| Links: |
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| Themen: |
059QF0KO0R |
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| Anmerkungen: |
Date Completed 09.03.2023 Date Revised 15.03.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1039/d2tb02734h |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352722738 |
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| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a This study introduces a multilamellar ceramide core-structured microvehicle platform for substantial skin barrier function recovery. Our approach essentially focused on fabricating bacterial cellulose nanofiber (BCNF)-enveloped ceramide-rich lipid microparticles (CerMPs) by solidifying BCNF-armored oil-in-water Pickering emulsions. The oil drops consisted of Ceramide NP (a phytosphingosine backbone N-acylated with a saturated stearic acid) and fatty alcohols (FAs) with a designated stoichiometry. The thin BCNF shell layer completely blocked the growth of ceramide molecular crystals from the CerMPs for a long time. The CerMP cores displayed a multilamellar structure wherein the interlayer distance and lateral packing could be manipulated using FAs with different alkyl chain lengths. The CerMPs remarkably lowered the trans-epidermal water loss while restoring the structural integrity of the epidermis in damaged skin. The results obtained herein highlight that the CerMP system provides a practical methodology for developing various types of skin-friendly formulations that can strengthen the skin barrier function | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Lee, Kun Bong |e verfasserin |4 aut | |
| 700 | 1 | |a Hwang, Jee-Hyun |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Boryeong |e verfasserin |4 aut | |
| 700 | 1 | |a Ryu, Hyunsun |e verfasserin |4 aut | |
| 700 | 1 | |a Noh, Minjoo |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Jun Bae |e verfasserin |4 aut | |
| 700 | 1 | |a Nam, Yoon Sung |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Kyung-Min |e verfasserin |4 aut | |
| 700 | 1 | |a Kim, Jin Woong |e verfasserin |4 aut | |
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