Insight into tetrahydrofuran lignans from Isatis indigotica fortune with neuroprotective and acetylcholinesterase inhibitor activity
Copyright © 2023 Elsevier Ltd. All rights reserved..
Nine tetrahydrofuran lignans, including three undescribed spiro-lignans, were isolated from Isatis indigotica Fortune (Brassicaceae). Extensive spectroscopic analyses achieved the structure elucidation of these tetrahydrofuran lignans, and quantum chemical calculation combined with the MAEΔΔδ parameter. Notably, isatispironeols A-B have a unique spiro[dienone-tetrahydrofuran] molecular core. These spiro[dienone-tetrahydrofuran] lignans showed comparable neuroprotective effects as the positive control in the H2O2-induced SH-SY5Y cells model. In addition, (-)-(7R,8S,1'R,7'R,8'R)-isatispironeol A possessed more significant AChE inhibitory activity, further interact sites were also predicted by the in silico assay.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:208 |
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| Enthalten in: |
Phytochemistry - 208(2023) vom: 05. Apr., Seite 113609 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Xi, Yu-Fei [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 07.03.2023 Date Revised 07.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.phytochem.2023.113609 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Nine tetrahydrofuran lignans, including three undescribed spiro-lignans, were isolated from Isatis indigotica Fortune (Brassicaceae). Extensive spectroscopic analyses achieved the structure elucidation of these tetrahydrofuran lignans, and quantum chemical calculation combined with the MAEΔΔδ parameter. Notably, isatispironeols A-B have a unique spiro[dienone-tetrahydrofuran] molecular core. These spiro[dienone-tetrahydrofuran] lignans showed comparable neuroprotective effects as the positive control in the H2O2-induced SH-SY5Y cells model. In addition, (-)-(7R,8S,1'R,7'R,8'R)-isatispironeol A possessed more significant AChE inhibitory activity, further interact sites were also predicted by the in silico assay | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Neuroprotective effects | |
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| 700 | 1 | |a Lin, Bin |e verfasserin |4 aut | |
| 700 | 1 | |a Yao, Guo-Dong |e verfasserin |4 aut | |
| 700 | 1 | |a Lou, Li-Li |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiao-Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Song, Shao-Jiang |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Xiao-Xiao |e verfasserin |4 aut | |
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