Longitudinal comparison of the developing gut virome in infants and their mothers
Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved..
The human gut virome and its early life development are poorly understood. Prior studies have captured single-point assessments with the evolution of the infant virome remaining largely unexplored. We performed viral metagenomic sequencing on stool samples collected longitudinally from a cohort of 53 infants from age 2 weeks to 3 years (80.7 billion reads), and from their mothers (9.8 billion reads) to examine and compare viromes. The asymptomatic infant virome consisted of bacteriophages, nonhuman dietary/environmental viruses, and human-host viruses, predominantly picornaviruses. In contrast, human-host viruses were largely absent from the maternal virome. Previously undescribed, sequence-divergent vertebrate viruses were detected in the maternal but not infant virome. As infants aged, the phage component evolved to resemble the maternal virome, but by age 3, the human-host component remained dissimilar from the maternal virome. Thus, early life virome development is determined predominantly by dietary, infectious, and environmental factors rather than direct maternal acquisition.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:31 |
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| Enthalten in: |
Cell host & microbe - 31(2023), 2 vom: 08. Feb., Seite 187-198.e3 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Walters, William A [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 13.02.2023 Date Revised 27.04.2024 published: Print Citation Status MEDLINE |
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| doi: |
10.1016/j.chom.2023.01.003 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Copyright © 2023 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a The human gut virome and its early life development are poorly understood. Prior studies have captured single-point assessments with the evolution of the infant virome remaining largely unexplored. We performed viral metagenomic sequencing on stool samples collected longitudinally from a cohort of 53 infants from age 2 weeks to 3 years (80.7 billion reads), and from their mothers (9.8 billion reads) to examine and compare viromes. The asymptomatic infant virome consisted of bacteriophages, nonhuman dietary/environmental viruses, and human-host viruses, predominantly picornaviruses. In contrast, human-host viruses were largely absent from the maternal virome. Previously undescribed, sequence-divergent vertebrate viruses were detected in the maternal but not infant virome. As infants aged, the phage component evolved to resemble the maternal virome, but by age 3, the human-host component remained dissimilar from the maternal virome. Thus, early life virome development is determined predominantly by dietary, infectious, and environmental factors rather than direct maternal acquisition | ||
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| 700 | 1 | |a Federman, Scot |e verfasserin |4 aut | |
| 700 | 1 | |a Stryke, Doug |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Yale |e verfasserin |4 aut | |
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| 700 | 1 | |a Parsonnet, Julie |e verfasserin |4 aut | |
| 700 | 1 | |a Chiu, Charles Y |e verfasserin |4 aut | |
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