Quercetin ameliorates acute acrylamide induced spleen injury
Acrylamide is used for industrial and laboratory purposes; it also is produced during cooking of carbohydrate-rich food at high temperature. We investigated the therapeutic potential of quercetin for treatment of acute acrylamide induced injury to the spleen. We used female albino rats treated with acrylamide for 10 days followed by oral administration of quercetin in three doses for 5 days. We observed significantly reduced total body weight, spleen weight, red blood cells, total proteins, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phophate dehydrogenase, reduced glutathione, concentration of serum IgG and IgM after acrylamide induced toxicity compared to controls. We also found that white blood cells, triglycerides, cholesterol and lipid oxidation were increased significantly after acrylamide induced toxicity in rats compared to controls. Histoarchitecture of spleen was affected adversely by acrylamide toxicity. Administration of quercetin ameliorated adverse effects of acrylamide in a dose-dependent manner. Quercetin appears to ameliorate acrylamide induced injury to the spleen by increasing endogenous antioxidants and improving histoarchitecture and immune function.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:98 |
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| Enthalten in: |
Biotechnic & histochemistry : official publication of the Biological Stain Commission - 98(2023), 4 vom: 02. Mai, Seite 221-229 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Shukla, Piyush [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 08.06.2023 Date Revised 08.06.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/10520295.2023.2172610 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM352652314 |
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| 245 | 1 | 0 | |a Quercetin ameliorates acute acrylamide induced spleen injury |
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| 520 | |a Acrylamide is used for industrial and laboratory purposes; it also is produced during cooking of carbohydrate-rich food at high temperature. We investigated the therapeutic potential of quercetin for treatment of acute acrylamide induced injury to the spleen. We used female albino rats treated with acrylamide for 10 days followed by oral administration of quercetin in three doses for 5 days. We observed significantly reduced total body weight, spleen weight, red blood cells, total proteins, superoxide dismutase, catalase, glutathione peroxidase, glutathione reductase, glucose-6-phophate dehydrogenase, reduced glutathione, concentration of serum IgG and IgM after acrylamide induced toxicity compared to controls. We also found that white blood cells, triglycerides, cholesterol and lipid oxidation were increased significantly after acrylamide induced toxicity in rats compared to controls. Histoarchitecture of spleen was affected adversely by acrylamide toxicity. Administration of quercetin ameliorated adverse effects of acrylamide in a dose-dependent manner. Quercetin appears to ameliorate acrylamide induced injury to the spleen by increasing endogenous antioxidants and improving histoarchitecture and immune function | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acrylamide | |
| 650 | 4 | |a antioxidants | |
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| 700 | 1 | |a Sahu, Naresh Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Raj |e verfasserin |4 aut | |
| 700 | 1 | |a Dhalla, Deep Kaur |e verfasserin |4 aut | |
| 700 | 1 | |a Rakshit, Samrat |e verfasserin |4 aut | |
| 700 | 1 | |a Bhadauria, Monika |e verfasserin |4 aut | |
| 700 | 1 | |a Agrawal, Narottam Das |e verfasserin |4 aut | |
| 700 | 1 | |a Shrivastava, Sadhana |e verfasserin |4 aut | |
| 700 | 1 | |a Shukla, Sangeeta |e verfasserin |4 aut | |
| 700 | 1 | |a Nirala, Satendra Kumar |e verfasserin |4 aut | |
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