Cost-effectiveness analysis of computer-aided detection systems for colonoscopy in Japan
© 2023 Japan Gastroenterological Endoscopy Society..
OBJECTIVES: The usefulness of computer-aided detection systems (CADe) for colonoscopy has been increasingly reported. In many countries, however, data on the cost-effectiveness of their use are lacking; consequently, CADe for colonoscopy has not been covered by health insurance. We aimed to evaluate the cost-effectiveness of colonoscopy using CADe in Japan.
METHODS: We conducted a simulation model analysis using Japanese data to examine the cost-effectiveness of colonoscopy with and without CADe for a population aged 40-74 years who received colorectal cancer (CRC) screening with a fecal immunochemical test (FIT). The rates of receiving FIT screening and colonoscopy following a positive FIT were set as 40% and 70%, respectively. The sensitivities of FIT for advanced adenomas and CRC Dukes' A-D were 26.5% and 52.8-78.3%, respectively. CADe colonoscopy was judged to be cost-effective when its incremental cost-effectiveness ratio (ICER) was below JPY 5,000,000 per quality-adjusted life-years (QALYs) gained.
RESULTS: Compared to conventional colonoscopy, CADe colonoscopy showed a higher QALY (20.4098 vs. 20.4088) and lower CRC incidence (2373 vs. 2415 per 100,000) and mortality (561 vs. 569 per 100,000). When the CADe cost was set at JPY 1000-6000, the ICER per QALY gained for CADe colonoscopy was lower than JPY 5,000,000 (JPY 796,328-4,971,274). The CADe cost threshold at which the ICER for CADe colonoscopy exceeded JPY 5,000,000 was JPY 6040.
CONCLUSIONS: Computer-aided detection systems for colonoscopy has the potential to be cost-effective when the CADe cost is up to JPY 6000. These results suggest that the insurance reimbursement of CADe for colonoscopy is reasonable.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society - 35(2023), 7 vom: 14. Nov., Seite 891-899 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sekiguchi, Masau [VerfasserIn] |
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| Links: |
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| Themen: |
Colonoscopy |
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| Anmerkungen: |
Date Completed 13.11.2023 Date Revised 13.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1111/den.14532 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM352625805 |
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| 245 | 1 | 0 | |a Cost-effectiveness analysis of computer-aided detection systems for colonoscopy in Japan |
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| 500 | |a Date Revised 13.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Japan Gastroenterological Endoscopy Society. | ||
| 520 | |a OBJECTIVES: The usefulness of computer-aided detection systems (CADe) for colonoscopy has been increasingly reported. In many countries, however, data on the cost-effectiveness of their use are lacking; consequently, CADe for colonoscopy has not been covered by health insurance. We aimed to evaluate the cost-effectiveness of colonoscopy using CADe in Japan | ||
| 520 | |a METHODS: We conducted a simulation model analysis using Japanese data to examine the cost-effectiveness of colonoscopy with and without CADe for a population aged 40-74 years who received colorectal cancer (CRC) screening with a fecal immunochemical test (FIT). The rates of receiving FIT screening and colonoscopy following a positive FIT were set as 40% and 70%, respectively. The sensitivities of FIT for advanced adenomas and CRC Dukes' A-D were 26.5% and 52.8-78.3%, respectively. CADe colonoscopy was judged to be cost-effective when its incremental cost-effectiveness ratio (ICER) was below JPY 5,000,000 per quality-adjusted life-years (QALYs) gained | ||
| 520 | |a RESULTS: Compared to conventional colonoscopy, CADe colonoscopy showed a higher QALY (20.4098 vs. 20.4088) and lower CRC incidence (2373 vs. 2415 per 100,000) and mortality (561 vs. 569 per 100,000). When the CADe cost was set at JPY 1000-6000, the ICER per QALY gained for CADe colonoscopy was lower than JPY 5,000,000 (JPY 796,328-4,971,274). The CADe cost threshold at which the ICER for CADe colonoscopy exceeded JPY 5,000,000 was JPY 6040 | ||
| 520 | |a CONCLUSIONS: Computer-aided detection systems for colonoscopy has the potential to be cost-effective when the CADe cost is up to JPY 6000. These results suggest that the insurance reimbursement of CADe for colonoscopy is reasonable | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a colonoscopy | |
| 650 | 4 | |a colorectal cancer screening | |
| 650 | 4 | |a computer-aided detection | |
| 650 | 4 | |a cost-effectiveness | |
| 650 | 4 | |a fecal immunochemical test | |
| 700 | 1 | |a Igarashi, Ataru |e verfasserin |4 aut | |
| 700 | 1 | |a Toyoshima, Naoya |e verfasserin |4 aut | |
| 700 | 1 | |a Takamaru, Hiroyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Yamada, Masayoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Esaki, Minoru |e verfasserin |4 aut | |
| 700 | 1 | |a Kobayashi, Nozomu |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Yutaka |e verfasserin |4 aut | |
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