Impact of formulation design and lyophilisation on the physicochemical characteristics of finasteride nanosystems
The fundamental purpose of this study was to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery. The FNS-NS was fabricated using an ultrasonication technique. The impact of two different cryoprotectants on the physicochemical characteristics of FNS-NS before and after lyophilisation was thoroughly investigated. The lyophilised FNS-NS had spherical shape with particle size lied between 188.6 nm ± 4.4 and 298.7 nm ± 4.7, low PDI values (0.26 ± 0.02 to 0.32 ± 0.02) and zeta potential ranging from -38.3 to +53.3 mV. The confocal laser microscopy depicted a comparatively higher cellular internalisation achieved for undecorated FNS-NS with respect to its chitosan-decorated counterpart. The lyophilised FNS-NS was stable for 90 days at proper storage conditions. The FNS-NS with 15% trehalose had appropriate physicochemical attributes that could be a promising carrier for topical delivery to treat androgenic alopecia.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:40 |
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| Enthalten in: |
Journal of microencapsulation - 40(2023), 2 vom: 01. März, Seite 106-123 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Irfan, Malik Muhammad [VerfasserIn] |
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| Links: |
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| Themen: |
57GNO57U7G |
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| Anmerkungen: |
Date Completed 27.03.2023 Date Revised 27.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2023.2178537 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352595140 |
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| 500 | |a Date Revised 27.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The fundamental purpose of this study was to develop a stable lyophilised finasteride nanosystem (FNS-NS) for topical delivery. The FNS-NS was fabricated using an ultrasonication technique. The impact of two different cryoprotectants on the physicochemical characteristics of FNS-NS before and after lyophilisation was thoroughly investigated. The lyophilised FNS-NS had spherical shape with particle size lied between 188.6 nm ± 4.4 and 298.7 nm ± 4.7, low PDI values (0.26 ± 0.02 to 0.32 ± 0.02) and zeta potential ranging from -38.3 to +53.3 mV. The confocal laser microscopy depicted a comparatively higher cellular internalisation achieved for undecorated FNS-NS with respect to its chitosan-decorated counterpart. The lyophilised FNS-NS was stable for 90 days at proper storage conditions. The FNS-NS with 15% trehalose had appropriate physicochemical attributes that could be a promising carrier for topical delivery to treat androgenic alopecia | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Finasteride | |
| 650 | 4 | |a cellular uptake | |
| 650 | 4 | |a chitosan | |
| 650 | 4 | |a lyophilisation | |
| 650 | 4 | |a nanosystem | |
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| 650 | 7 | |a 57GNO57U7G |2 NLM | |
| 700 | 1 | |a Shah, Shefaat Ullah |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Kifayat Ullah |e verfasserin |4 aut | |
| 700 | 1 | |a Anton, Nicolas |e verfasserin |4 aut | |
| 700 | 1 | |a Idoux-Gillet, Ysia |e verfasserin |4 aut | |
| 700 | 1 | |a Conzatti, Guillaume |e verfasserin |4 aut | |
| 700 | 1 | |a Shah, Kifayat Ullah |e verfasserin |4 aut | |
| 700 | 1 | |a Perennes, Elise |e verfasserin |4 aut | |
| 700 | 1 | |a Vandamme, Thierry |e verfasserin |4 aut | |
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