Nickel-catalyzed divergent Mizoroki-Heck reaction of 1,3-dienes
© 2023. The Author(s)..
Developing efficient strategies to realize divergent arylation of dienes has been a long-standing synthetic challenge. Herein, a nickel catalyzed divergent Mizoroki-Heck reaction of 1,3-dienes has been demonstrated through the regulation of ligands and additives. In the presence of Mn/NEt3, the Mizoroki-Heck reaction of dienes delivers linear products under Ni(dppe)Cl2 catalysis in high regio- and stereoselectivities. With the help of catalytic amount of organoboron and NaF, the use of bulky ligand IPr diverts the selectivity from linear products to branched products. Highly aryl-substituted compounds can be transformed from dispersive Mizoroki-Heck products programmatically. Preliminary experimental studies are carried out to elucidate the role of additives.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Nature communications - 14(2023), 1 vom: 06. Feb., Seite 651 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Wei-Song [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 07.02.2023 Date Revised 09.02.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1038/s41467-023-36237-1 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM35256928X |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2023. The Author(s). | ||
| 520 | |a Developing efficient strategies to realize divergent arylation of dienes has been a long-standing synthetic challenge. Herein, a nickel catalyzed divergent Mizoroki-Heck reaction of 1,3-dienes has been demonstrated through the regulation of ligands and additives. In the presence of Mn/NEt3, the Mizoroki-Heck reaction of dienes delivers linear products under Ni(dppe)Cl2 catalysis in high regio- and stereoselectivities. With the help of catalytic amount of organoboron and NaF, the use of bulky ligand IPr diverts the selectivity from linear products to branched products. Highly aryl-substituted compounds can be transformed from dispersive Mizoroki-Heck products programmatically. Preliminary experimental studies are carried out to elucidate the role of additives | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Li, Ying |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiang-Xin |e verfasserin |4 aut | |
| 700 | 1 | |a Mei, Yong-Kang |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Bing-Zhi |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Qing-An |e verfasserin |4 aut | |
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