Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis
BACKGROUND: The increasing prevalence of diabetic ketoacidosis (DKA) related admissions poses a significant burden on the healthcare systems globally. However, data regarding the predictors of healthcare resource utilization in DKA is limited and inconsistent. This study aimed to identify key predictors of hospital length of stay (LOS), readmission and recurrent DKA episodes.
METHODS: We undertook a retrospective cross-sectional analysis of all DKA admissions from 2015 to 2021 across four hospitals in Qatar. The primary outcomes were the length of stay (LOS), 90-day readmission and 6-month and 1-year DKA recurrence.
RESULTS: We included 922 patients with a median age of 35 years (25-45). 62% were males with type-1 diabetes-mellitus (T1DM) and type-2 DM (T2DM), present in 52% and 48% of patients. The median LOS was 2.6 days (IQR 1.1-4.8), and the median DKA resolution time was 18 h (10.5-29). Male-gender, new-onset DM, higher Charlson Comorbidity Index (CCI), lower haemoglobin, sodium and potassium, higher urea, longer DKA duration and MICU admission predicted a longer LOS in a multivariate regression analysis. None of the factors were significantly associated with 90-day readmission. Patients with pre-existing T1DM were more likely to have a six-month DKA recurrence than pre-existing T2DM. Patients with a 6-month DKA recurrence, female gender and T1DM had higher odds of 12-month recurrence, whereas a consult with a diabetes educator at the index admission was associated with decreased odds of recurrence.
CONCLUSIONS/INTERPRETATION: This is the most extensive study from the Middle-East region reporting on LOS, readmissions and the recurrence of DKA. Results from this study with a diverse population may be valuable for physicians and healthcare systems to decrease the diabetes-related healthcare burden in DKA patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:55 |
|---|---|
| Enthalten in: |
Annals of medicine - 55(2023), 1 vom: 01. Dez., Seite 533-542 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Ata, Fateen [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
DKA |
|---|
| Anmerkungen: |
Date Completed 08.02.2023 Date Revised 19.01.2024 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1080/07853890.2023.2175031 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM352555106 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM352555106 | ||
| 003 | DE-627 | ||
| 005 | 20240119231831.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/07853890.2023.2175031 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1264.xml |
| 035 | |a (DE-627)NLM352555106 | ||
| 035 | |a (NLM)36745515 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Ata, Fateen |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Clinical and biochemical determinants of length of stay, readmission and recurrence in patients admitted with diabetic ketoacidosis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.02.2023 | ||
| 500 | |a Date Revised 19.01.2024 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: The increasing prevalence of diabetic ketoacidosis (DKA) related admissions poses a significant burden on the healthcare systems globally. However, data regarding the predictors of healthcare resource utilization in DKA is limited and inconsistent. This study aimed to identify key predictors of hospital length of stay (LOS), readmission and recurrent DKA episodes | ||
| 520 | |a METHODS: We undertook a retrospective cross-sectional analysis of all DKA admissions from 2015 to 2021 across four hospitals in Qatar. The primary outcomes were the length of stay (LOS), 90-day readmission and 6-month and 1-year DKA recurrence | ||
| 520 | |a RESULTS: We included 922 patients with a median age of 35 years (25-45). 62% were males with type-1 diabetes-mellitus (T1DM) and type-2 DM (T2DM), present in 52% and 48% of patients. The median LOS was 2.6 days (IQR 1.1-4.8), and the median DKA resolution time was 18 h (10.5-29). Male-gender, new-onset DM, higher Charlson Comorbidity Index (CCI), lower haemoglobin, sodium and potassium, higher urea, longer DKA duration and MICU admission predicted a longer LOS in a multivariate regression analysis. None of the factors were significantly associated with 90-day readmission. Patients with pre-existing T1DM were more likely to have a six-month DKA recurrence than pre-existing T2DM. Patients with a 6-month DKA recurrence, female gender and T1DM had higher odds of 12-month recurrence, whereas a consult with a diabetes educator at the index admission was associated with decreased odds of recurrence | ||
| 520 | |a CONCLUSIONS/INTERPRETATION: This is the most extensive study from the Middle-East region reporting on LOS, readmissions and the recurrence of DKA. Results from this study with a diverse population may be valuable for physicians and healthcare systems to decrease the diabetes-related healthcare burden in DKA patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a DKA | |
| 650 | 4 | |a Diabetic ketoacidosis | |
| 650 | 4 | |a length of stay | |
| 650 | 4 | |a readmission | |
| 650 | 4 | |a recurrence | |
| 650 | 4 | |a type 1 diabetes | |
| 650 | 4 | |a type 2 diabetes | |
| 700 | 1 | |a Khan, Adeel Ahmad |e verfasserin |4 aut | |
| 700 | 1 | |a Khamees, Ibrahim |e verfasserin |4 aut | |
| 700 | 1 | |a Iqbal, Phool |e verfasserin |4 aut | |
| 700 | 1 | |a Yousaf, Zohaib |e verfasserin |4 aut | |
| 700 | 1 | |a Mohammed, Bayan Z M |e verfasserin |4 aut | |
| 700 | 1 | |a Aboshdid, Reham |e verfasserin |4 aut | |
| 700 | 1 | |a Marzouk, Sandy K K |e verfasserin |4 aut | |
| 700 | 1 | |a Barjas, Haidar |e verfasserin |4 aut | |
| 700 | 1 | |a Khalid, Madiha |e verfasserin |4 aut | |
| 700 | 1 | |a El Madhoun, Ihab |e verfasserin |4 aut | |
| 700 | 1 | |a Bashir, Mohammed |e verfasserin |4 aut | |
| 700 | 1 | |a Kartha, Anand |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of medicine |d 1996 |g 55(2023), 1 vom: 01. Dez., Seite 533-542 |w (DE-627)NLM012634972 |x 1365-2060 |7 nnns |
| 773 | 1 | 8 | |g volume:55 |g year:2023 |g number:1 |g day:01 |g month:12 |g pages:533-542 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/07853890.2023.2175031 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 55 |j 2023 |e 1 |b 01 |c 12 |h 533-542 | ||