Low-power laser in increasing doses improve wound healing process in rats
© 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature..
Low-power laser has been studied and applied as an auxiliary tool in wound healing. However, as it is a therapy with several variables to be controlled, there is great difficulty in establishing protocols and comparing its efficacy. Therefore, the objective of this study was to evaluate the effects of the use of low-power laser in fixed and crescent doses in the healing of skin wounds in rats. Seventy-five male Wistar rats were divided into three groups: G1 with animals that did not receive laser radiation; G2 with animals treated with fixed dose of 3 J/cm2 laser; G3 with animals treated with laser in increasing doses of 1 J/cm2, 3 J/cm2, 5 J/cm2. Macroscopic and histological analysis were performed. The lowest intensity of PMN was observed in the irradiated groups and G3 had lower intensity of this infiltrate compared to G1 and G2 (p <0.05). On the seventh day of injury, PMN infiltrate decreased in all groups, especially in G3 (p<0.05). It was observed that G2 had more blood vessels than G1 and G3 after 7 days of wound creation (p ˂ 0.05). Collagen quantification showed that laser-treated groups have increased collagen deposition. Different responses in the wound healing process were observed comparing G2 and G3 groups. The fluence of 1J/cm2 presented better results in the anti-inflammatory action than 3 J/cm2, although G3 presented the greatest amount of total collagen after ten days of treatment.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
|---|---|
| Enthalten in: |
Lasers in medical science - 38(2023), 1 vom: 02. Feb., Seite 60 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
de Oliveira, Leiny Paula [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
9007-34-5 |
|---|
| Anmerkungen: |
Date Completed 06.02.2023 Date Revised 22.12.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s10103-023-03716-2 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM352395125 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM352395125 | ||
| 003 | DE-627 | ||
| 005 | 20231227135815.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s10103-023-03716-2 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1235.xml |
| 035 | |a (DE-627)NLM352395125 | ||
| 035 | |a (NLM)36729262 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a de Oliveira, Leiny Paula |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Low-power laser in increasing doses improve wound healing process in rats |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 06.02.2023 | ||
| 500 | |a Date Revised 22.12.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature. | ||
| 520 | |a Low-power laser has been studied and applied as an auxiliary tool in wound healing. However, as it is a therapy with several variables to be controlled, there is great difficulty in establishing protocols and comparing its efficacy. Therefore, the objective of this study was to evaluate the effects of the use of low-power laser in fixed and crescent doses in the healing of skin wounds in rats. Seventy-five male Wistar rats were divided into three groups: G1 with animals that did not receive laser radiation; G2 with animals treated with fixed dose of 3 J/cm2 laser; G3 with animals treated with laser in increasing doses of 1 J/cm2, 3 J/cm2, 5 J/cm2. Macroscopic and histological analysis were performed. The lowest intensity of PMN was observed in the irradiated groups and G3 had lower intensity of this infiltrate compared to G1 and G2 (p <0.05). On the seventh day of injury, PMN infiltrate decreased in all groups, especially in G3 (p<0.05). It was observed that G2 had more blood vessels than G1 and G3 after 7 days of wound creation (p ˂ 0.05). Collagen quantification showed that laser-treated groups have increased collagen deposition. Different responses in the wound healing process were observed comparing G2 and G3 groups. The fluence of 1J/cm2 presented better results in the anti-inflammatory action than 3 J/cm2, although G3 presented the greatest amount of total collagen after ten days of treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Collagen deposition | |
| 650 | 4 | |a Energy density | |
| 650 | 4 | |a Inflammation | |
| 650 | 4 | |a Tissue repair | |
| 650 | 7 | |a Collagen |2 NLM | |
| 650 | 7 | |a 9007-34-5 |2 NLM | |
| 700 | 1 | |a de Lima Chagas, Angelica |e verfasserin |4 aut | |
| 700 | 1 | |a de Souza, Tainara Ribeiro |e verfasserin |4 aut | |
| 700 | 1 | |a Araújo, Isabela Rodrigues |e verfasserin |4 aut | |
| 700 | 1 | |a de Menezes, Liliana Borges |e verfasserin |4 aut | |
| 700 | 1 | |a Miguel, Marina Pacheco |e verfasserin |4 aut | |
| 700 | 1 | |a Vulcani, Valcinir Aloisio Scalla |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Lasers in medical science |d 1996 |g 38(2023), 1 vom: 02. Feb., Seite 60 |w (DE-627)NLM085855936 |x 1435-604X |7 nnns |
| 773 | 1 | 8 | |g volume:38 |g year:2023 |g number:1 |g day:02 |g month:02 |g pages:60 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s10103-023-03716-2 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 38 |j 2023 |e 1 |b 02 |c 02 |h 60 | ||