WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria
© The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene..
The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS to community health workers with little training and supervision. This non-randomized, operational research has provided useful information to guide the implementation of RAS but is subject to bias and confounding and cannot be used to assess treatment effects. Parenteral artesunate reduces severe malaria mortality and a large body of evidence also shows RAS has lifesaving efficacy. There is now more than a decade of delay in conducting the necessary engagement and training required for successful deployment of RAS. Further delays will result in more preventable deaths.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:117 |
|---|---|
| Enthalten in: |
Transactions of the Royal Society of Tropical Medicine and Hygiene - 117(2023), 7 vom: 04. Juli, Seite 536-538 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Peto, Thomas J [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
60W3249T9M |
|---|
| Anmerkungen: |
Date Completed 05.07.2023 Date Revised 06.07.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/trstmh/trad002 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM352327847 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM352327847 | ||
| 003 | DE-627 | ||
| 005 | 20231226053451.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/trstmh/trad002 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1174.xml |
| 035 | |a (DE-627)NLM352327847 | ||
| 035 | |a (NLM)36722432 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Peto, Thomas J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a WHO should accelerate, not stall, rectal artesunate deployment for pre-referral treatment of severe malaria |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 05.07.2023 | ||
| 500 | |a Date Revised 06.07.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2023. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. | ||
| 520 | |a The recent World Health Organization moratorium on rectal artesunate (RAS) for pre-referral treatment of severe childhood malaria is costing young lives. The decision was based on disappointing findings from a large observational study that provided RAS to community health workers with little training and supervision. This non-randomized, operational research has provided useful information to guide the implementation of RAS but is subject to bias and confounding and cannot be used to assess treatment effects. Parenteral artesunate reduces severe malaria mortality and a large body of evidence also shows RAS has lifesaving efficacy. There is now more than a decade of delay in conducting the necessary engagement and training required for successful deployment of RAS. Further delays will result in more preventable deaths | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 7 | |a Artesunate |2 NLM | |
| 650 | 7 | |a 60W3249T9M |2 NLM | |
| 650 | 7 | |a Antimalarials |2 NLM | |
| 650 | 7 | |a Artemisinins |2 NLM | |
| 700 | 1 | |a Watson, James A |e verfasserin |4 aut | |
| 700 | 1 | |a White, Nicholas J |e verfasserin |4 aut | |
| 700 | 1 | |a Dondorp, Arjen M |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Transactions of the Royal Society of Tropical Medicine and Hygiene |d 1945 |g 117(2023), 7 vom: 04. Juli, Seite 536-538 |w (DE-627)NLM000035653 |x 1878-3503 |7 nnns |
| 773 | 1 | 8 | |g volume:117 |g year:2023 |g number:7 |g day:04 |g month:07 |g pages:536-538 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/trstmh/trad002 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 117 |j 2023 |e 7 |b 04 |c 07 |h 536-538 | ||