Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation
Dietary potassium (K+) supplementation is associated with a lowering effect in blood pressure (BP), but not all studies agree. Here, we examined the effects of short- and long-term K+ supplementation on BP in mice, whether differences depend on the accompanying anion or the sodium (Na+) intake and molecular alterations in the kidney that may underlie BP changes. Relative to the control diet, BP was higher in mice fed a high NaCl (1.57% Na+) diet for 7 weeks or fed a K+-free diet for 2 weeks. BP was highest on a K+-free/high NaCl diet. Commensurate with increased abundance and phosphorylation of the thiazide sensitive sodium-chloride-cotransporter (NCC) on the K+-free/high NaCl diet, BP returned to normal with thiazides. Three weeks of a high K+ diet (5% K+) increased BP (predominantly during the night) independently of dietary Na+ or anion intake. Conversely, 4 days of KCl feeding reduced BP. Both feeding periods resulted in lower NCC levels but in increased levels of cleaved (active) α and γ subunits of the epithelial Na+ channel ENaC. The elevated BP after chronic K+ feeding was reduced by amiloride but not thiazide. Our results suggest that dietary K+ has an optimal threshold where it may be most effective for cardiovascular health.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:8 |
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| Enthalten in: |
JCI insight - 8(2023), 5 vom: 08. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Little, Robert [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 09.03.2023 Date Revised 08.04.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1172/jci.insight.156437 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM352301244 |
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| 245 | 1 | 0 | |a Dissociation of sodium-chloride cotransporter expression and blood pressure during chronic high dietary potassium supplementation |
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| 520 | |a Dietary potassium (K+) supplementation is associated with a lowering effect in blood pressure (BP), but not all studies agree. Here, we examined the effects of short- and long-term K+ supplementation on BP in mice, whether differences depend on the accompanying anion or the sodium (Na+) intake and molecular alterations in the kidney that may underlie BP changes. Relative to the control diet, BP was higher in mice fed a high NaCl (1.57% Na+) diet for 7 weeks or fed a K+-free diet for 2 weeks. BP was highest on a K+-free/high NaCl diet. Commensurate with increased abundance and phosphorylation of the thiazide sensitive sodium-chloride-cotransporter (NCC) on the K+-free/high NaCl diet, BP returned to normal with thiazides. Three weeks of a high K+ diet (5% K+) increased BP (predominantly during the night) independently of dietary Na+ or anion intake. Conversely, 4 days of KCl feeding reduced BP. Both feeding periods resulted in lower NCC levels but in increased levels of cleaved (active) α and γ subunits of the epithelial Na+ channel ENaC. The elevated BP after chronic K+ feeding was reduced by amiloride but not thiazide. Our results suggest that dietary K+ has an optimal threshold where it may be most effective for cardiovascular health | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Epithelial transport of ions and water | |
| 650 | 4 | |a Hypertension | |
| 650 | 4 | |a Nephrology | |
| 650 | 4 | |a Sodium channels | |
| 650 | 7 | |a Sodium Chloride Symporters |2 NLM | |
| 650 | 7 | |a Potassium, Dietary |2 NLM | |
| 650 | 7 | |a Sodium Chloride |2 NLM | |
| 650 | 7 | |a 451W47IQ8X |2 NLM | |
| 650 | 7 | |a Epithelial Sodium Channels |2 NLM | |
| 650 | 7 | |a Sodium |2 NLM | |
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| 650 | 7 | |a Thiazides |2 NLM | |
| 700 | 1 | |a Murali, Sathish K |e verfasserin |4 aut | |
| 700 | 1 | |a Poulsen, Søren B |e verfasserin |4 aut | |
| 700 | 1 | |a Grimm, Paul R |e verfasserin |4 aut | |
| 700 | 1 | |a Assmus, Adrienne |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Lei |e verfasserin |4 aut | |
| 700 | 1 | |a Ivy, Jessica R |e verfasserin |4 aut | |
| 700 | 1 | |a Hoorn, Ewout J |e verfasserin |4 aut | |
| 700 | 1 | |a Matchkov, Vladimir |e verfasserin |4 aut | |
| 700 | 1 | |a Welling, Paul A |e verfasserin |4 aut | |
| 700 | 1 | |a Fenton, Robert A |e verfasserin |4 aut | |
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