Neuropathology II : diseases of the central and peripheral nervous systems : Outlook on new techniques in electron microscopy
© 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature..
In the diagnosis of diseases of the central and peripheral nervous systems, the use of electron microscopic analyses has become rare these days. However, there are questions in which the method is helpful in confirming the etiopathogenesis of the disease. Hereditary neurodegenerative and metabolic diseases, such as the lysosomal storage disease neuronal ceroid lipofuscinosis, are associated with pathognomonic storage products not only in the central nervous system (CNS) but also in extracerebral tissues such as sweat glands and lymphocytes. These tissues are easily accessible and thus function as "windows to the CNS". In addition, there are new methods that overcome limitations of conventional electron microscopy and may improve ultrastructural diagnostics. This is particularly important for the correct classification of viral particles such as SARS-CoV‑2, leading to a better understanding of COVID19-associated diseases in the CNS and peripheral nervous system.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
|---|---|
| Enthalten in: |
Pathologie (Heidelberg, Germany) - 44(2023), 2 vom: 14. März, Seite 113-120 |
| Sprache: |
Deutsch |
|---|
| Weiterer Titel: |
Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems : Ausblick auf neue Techniken in der Elektronenmikroskopie |
|---|
| Beteiligte Personen: |
Schänzer, Anne [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COVID-19 |
|---|
| Anmerkungen: |
Date Completed 07.03.2023 Date Revised 10.03.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00292-022-01178-x |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM352261382 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM352261382 | ||
| 003 | DE-627 | ||
| 005 | 20231226053318.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||ger c | ||
| 024 | 7 | |a 10.1007/s00292-022-01178-x |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1174.xml |
| 035 | |a (DE-627)NLM352261382 | ||
| 035 | |a (NLM)36715732 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a ger | ||
| 100 | 1 | |a Schänzer, Anne |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Neuropathology II |b diseases of the central and peripheral nervous systems : Outlook on new techniques in electron microscopy |
| 246 | 3 | 3 | |a Neuropathologie II: Erkrankungen des zentralen und peripheren Nervensystems : Ausblick auf neue Techniken in der Elektronenmikroskopie |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 07.03.2023 | ||
| 500 | |a Date Revised 10.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature. | ||
| 520 | |a In the diagnosis of diseases of the central and peripheral nervous systems, the use of electron microscopic analyses has become rare these days. However, there are questions in which the method is helpful in confirming the etiopathogenesis of the disease. Hereditary neurodegenerative and metabolic diseases, such as the lysosomal storage disease neuronal ceroid lipofuscinosis, are associated with pathognomonic storage products not only in the central nervous system (CNS) but also in extracerebral tissues such as sweat glands and lymphocytes. These tissues are easily accessible and thus function as "windows to the CNS". In addition, there are new methods that overcome limitations of conventional electron microscopy and may improve ultrastructural diagnostics. This is particularly important for the correct classification of viral particles such as SARS-CoV‑2, leading to a better understanding of COVID19-associated diseases in the CNS and peripheral nervous system | ||
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Electron microscopy | |
| 650 | 4 | |a Lysosomal storage disease | |
| 650 | 4 | |a Neuronal ceroid-lipofuscinose | |
| 650 | 4 | |a SARS-CoV‑2 | |
| 700 | 1 | |a Dittmayer, Carsten |e verfasserin |4 aut | |
| 700 | 1 | |a Weis, Joachim |e verfasserin |4 aut | |
| 700 | 1 | |a Stenzel, Werner |e verfasserin |4 aut | |
| 700 | 1 | |a Goebel, Hans-Hilmar |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pathologie (Heidelberg, Germany) |d 2022 |g 44(2023), 2 vom: 14. März, Seite 113-120 |w (DE-627)NLM337237387 |x 2731-7196 |7 nnns |
| 773 | 1 | 8 | |g volume:44 |g year:2023 |g number:2 |g day:14 |g month:03 |g pages:113-120 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00292-022-01178-x |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 44 |j 2023 |e 2 |b 14 |c 03 |h 113-120 | ||