Homodyne time-of-flight acousto-optic imaging for low-gain photodetector
© Korean Society of Medical and Biological Engineering 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law..
Acousto-optics imaging (AOI) is a hybrid imaging modality that is capable of mapping the light fluence rate in deep tissue by local ultrasound modulation of the diffused photons. Since the intensity of the modulated photons is relatively low, AOI systems often rely on high-gain photodetectors, e.g. photomultiplier tubes (PMTs), which limit scalability due to size and cost and may significantly increase the relative shot-noise in the detected signal due to low quantum yields or gain noise. In this work, we have developed a homodyne AOI scheme in which the modulated photons are amplified by interference with a reference beam, enabling their detection with a single low-gain photodetector in reflection-mode configuration. We experimentally demonstrate our approach with a silicon photodiode, achieving over a 4-fold improvement in SNR in comparison to a PMT-based setup. The increased SNR manifested in lower background noise level thus enabling deeper imaging depths. The use of a fiber-based configuration enables the integration of our scheme in a hand-held AOI probe.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:13 |
|---|---|
| Enthalten in: |
Biomedical engineering letters - 13(2023), 1 vom: 20. Feb., Seite 49-56 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Levi, Ahiad R [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Acousto-optics |
|---|
| Anmerkungen: |
Date Revised 20.11.2023 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1007/s13534-022-00252-w |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM352215771 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM352215771 | ||
| 003 | DE-627 | ||
| 005 | 20231226053218.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s13534-022-00252-w |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1174.xml |
| 035 | |a (DE-627)NLM352215771 | ||
| 035 | |a (NLM)36711164 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Levi, Ahiad R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Homodyne time-of-flight acousto-optic imaging for low-gain photodetector |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 20.11.2023 | ||
| 500 | |a published: Electronic-eCollection | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © Korean Society of Medical and Biological Engineering 2022, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. | ||
| 520 | |a Acousto-optics imaging (AOI) is a hybrid imaging modality that is capable of mapping the light fluence rate in deep tissue by local ultrasound modulation of the diffused photons. Since the intensity of the modulated photons is relatively low, AOI systems often rely on high-gain photodetectors, e.g. photomultiplier tubes (PMTs), which limit scalability due to size and cost and may significantly increase the relative shot-noise in the detected signal due to low quantum yields or gain noise. In this work, we have developed a homodyne AOI scheme in which the modulated photons are amplified by interference with a reference beam, enabling their detection with a single low-gain photodetector in reflection-mode configuration. We experimentally demonstrate our approach with a silicon photodiode, achieving over a 4-fold improvement in SNR in comparison to a PMT-based setup. The increased SNR manifested in lower background noise level thus enabling deeper imaging depths. The use of a fiber-based configuration enables the integration of our scheme in a hand-held AOI probe | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Acousto-optics | |
| 650 | 4 | |a Coherent detection | |
| 650 | 4 | |a Homodyne | |
| 650 | 4 | |a Medical imaging | |
| 650 | 4 | |a Preclinical system | |
| 650 | 4 | |a Ultrasound modulated optoacoustics | |
| 700 | 1 | |a Hazan, Yoav |e verfasserin |4 aut | |
| 700 | 1 | |a Lev, Aner |e verfasserin |4 aut | |
| 700 | 1 | |a Sfez, Bruno G |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenthal, Amir |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Biomedical engineering letters |d 2012 |g 13(2023), 1 vom: 20. Feb., Seite 49-56 |w (DE-627)NLM236949330 |x 2093-985X |7 nnns |
| 773 | 1 | 8 | |g volume:13 |g year:2023 |g number:1 |g day:20 |g month:02 |g pages:49-56 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s13534-022-00252-w |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 13 |j 2023 |e 1 |b 20 |c 02 |h 49-56 | ||