ALFF response interaction with learning during feedback in individuals with multiple sclerosis
Copyright © 2023. Published by Elsevier B.V..
Amplitude of low-frequency fluctuations (ALFF) is defined as changes of BOLD signal during resting state (RS) brain activity. Previous studies identified differences in RS activation between healthy and multiple sclerosis (MS) participants. However, no research has investigated the relationship between ALFF and learning in MS. We thus examine this here. Twenty-five MS and nineteen healthy participants performed a paired-associate word learning task where participants were presented with extrinsic or intrinsic performance feedback. Compared to healthy participants, MS participants showed higher local brain activation in the right thalamus. We also observed a positive correlation in the MS group between ALFF and extrinsic feedback within the left inferior frontal gyrus, and within the left superior temporal gyrus in association with intrinsic feedback. Healthy participants showed a positive correlation in the right fusiform gyrus between ALFF and extrinsic feedback. Findings suggest that while MS participants do not show a feedback learning impairment compared to the healthy participants, ALFF differences might suggest a general maladaptive pattern of task unrelated thalamic activation and adaptive activation in frontal and temporal regions. Results indicate that ALFF can be successfully used at capturing pathophysiological changes in local brain activation in MS in association with learning through feedback.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:70 |
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| Enthalten in: |
Multiple sclerosis and related disorders - 70(2023) vom: 13. Feb., Seite 104510 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dobryakova, Ekaterina [VerfasserIn] |
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| Links: |
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| Themen: |
Amplitude of low-frequency fluctuations |
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| Anmerkungen: |
Date Completed 14.03.2023 Date Revised 14.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.msard.2023.104510 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM352169249 |
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| 245 | 1 | 0 | |a ALFF response interaction with learning during feedback in individuals with multiple sclerosis |
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| 500 | |a Date Revised 14.03.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier B.V. | ||
| 520 | |a Amplitude of low-frequency fluctuations (ALFF) is defined as changes of BOLD signal during resting state (RS) brain activity. Previous studies identified differences in RS activation between healthy and multiple sclerosis (MS) participants. However, no research has investigated the relationship between ALFF and learning in MS. We thus examine this here. Twenty-five MS and nineteen healthy participants performed a paired-associate word learning task where participants were presented with extrinsic or intrinsic performance feedback. Compared to healthy participants, MS participants showed higher local brain activation in the right thalamus. We also observed a positive correlation in the MS group between ALFF and extrinsic feedback within the left inferior frontal gyrus, and within the left superior temporal gyrus in association with intrinsic feedback. Healthy participants showed a positive correlation in the right fusiform gyrus between ALFF and extrinsic feedback. Findings suggest that while MS participants do not show a feedback learning impairment compared to the healthy participants, ALFF differences might suggest a general maladaptive pattern of task unrelated thalamic activation and adaptive activation in frontal and temporal regions. Results indicate that ALFF can be successfully used at capturing pathophysiological changes in local brain activation in MS in association with learning through feedback | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Amplitude of low-frequency fluctuations | |
| 650 | 4 | |a Feedback | |
| 650 | 4 | |a Learning | |
| 650 | 4 | |a Multiple sclerosis | |
| 650 | 4 | |a Resting state | |
| 700 | 1 | |a Hafiz, Rakibul |e verfasserin |4 aut | |
| 700 | 1 | |a Iosipchuk, Olesya |e verfasserin |4 aut | |
| 700 | 1 | |a Sandry, Joshua |e verfasserin |4 aut | |
| 700 | 1 | |a Biswal, Bharat |e verfasserin |4 aut | |
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