Postvaccination Immunogenicity of BNT162b2 SARS-CoV-2 Vaccine and Its Predictors in Pediatric Inflammatory Bowel Disease
Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition..
OBJECTIVES: We prospectively compared the postvaccination immunity to messenger ribonucleic acid BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine of our pediatric patients over 12 years old with inflammatory bowel disease (IBD) to that of healthy controls and looked for predictors of its robustness.
METHODS: Anti-receptor binding domain, anti-spike S2, and anti-nucleocapsid immunoglobin-G (IgG) and immunoglobin-A levels were measured in 139 pediatric patients with IBD [65 fully vaccinated (2 doses), median age 16.3, interquartile range (IQR) 15.2-17.8 years, median time from vaccination (IQR) 61.0 (42.0-80.0) days] and 1744 controls (46, 37-57 years) using microblot array.
RESULTS: All IBD and control patients developed positive anti-receptor binding domain IgG antibodies at comparable titers. The proportion of observations with positive anti-spike S2 IgG was higher in patients with IBD than in controls [63% vs 21%, odds ratio 2.99 (1.51-5.90)], as was its titer [median (IQR) 485 (92-922) vs 79 [33-180] IU/mL]. Anti-receptor binding domain and anti-spike S2 IgG levels were associated with IBD status. We found an association between anti-spike S2 IgG levels and time since vaccination (β -4.85, 95% CI -7.14 to 2.71, P = 0.0001), history of SARS-CoV-2 polymerase chain reaction positivity (206.76, 95% CI 39.93-374.05, P = 0.0213), and anti-tumor necrosis factor treatment (-239.68, 95% CI -396.44-83.55, P = 0.0047). Forty-three percent of patients reported vaccination side effects (mostly mild). Forty-six percent of observations with positive anti-nucleocapsid IgG had a history of SARS-CoV-2 infection.
CONCLUSIONS: Patients with IBD produced higher levels of postvaccination anti-spike S2 antibodies than controls. Previous SARS-CoV-2 infection is associated with higher production of postvaccination antibodies and anti-tumor necrosis factor treatment with lower production.
Errataetall: |
CommentIn: J Pediatr Gastroenterol Nutr. 2023 Jun 1;76(6):e90. - PMID 36913707 |
---|---|
Medienart: |
E-Artikel |
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:76 |
---|---|
Enthalten in: |
Journal of pediatric gastroenterology and nutrition - 76(2023), 2 vom: 01. Feb., Seite e36-e44 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Bronsky, Jiri [VerfasserIn] |
---|
Links: |
---|
Themen: |
Antibodies, Viral |
---|
Anmerkungen: |
Date Completed 03.02.2023 Date Revised 22.08.2023 published: Print-Electronic CommentIn: J Pediatr Gastroenterol Nutr. 2023 Jun 1;76(6):e90. - PMID 36913707 Citation Status MEDLINE |
---|
doi: |
10.1097/MPG.0000000000003661 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM352161639 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM352161639 | ||
003 | DE-627 | ||
005 | 20231226053102.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1097/MPG.0000000000003661 |2 doi | |
028 | 5 | 2 | |a pubmed24n1173.xml |
035 | |a (DE-627)NLM352161639 | ||
035 | |a (NLM)36705698 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Bronsky, Jiri |e verfasserin |4 aut | |
245 | 1 | 0 | |a Postvaccination Immunogenicity of BNT162b2 SARS-CoV-2 Vaccine and Its Predictors in Pediatric Inflammatory Bowel Disease |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 03.02.2023 | ||
500 | |a Date Revised 22.08.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a CommentIn: J Pediatr Gastroenterol Nutr. 2023 Jun 1;76(6):e90. - PMID 36913707 | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright © 2022 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. | ||
520 | |a OBJECTIVES: We prospectively compared the postvaccination immunity to messenger ribonucleic acid BNT162b2 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine of our pediatric patients over 12 years old with inflammatory bowel disease (IBD) to that of healthy controls and looked for predictors of its robustness | ||
520 | |a METHODS: Anti-receptor binding domain, anti-spike S2, and anti-nucleocapsid immunoglobin-G (IgG) and immunoglobin-A levels were measured in 139 pediatric patients with IBD [65 fully vaccinated (2 doses), median age 16.3, interquartile range (IQR) 15.2-17.8 years, median time from vaccination (IQR) 61.0 (42.0-80.0) days] and 1744 controls (46, 37-57 years) using microblot array | ||
520 | |a RESULTS: All IBD and control patients developed positive anti-receptor binding domain IgG antibodies at comparable titers. The proportion of observations with positive anti-spike S2 IgG was higher in patients with IBD than in controls [63% vs 21%, odds ratio 2.99 (1.51-5.90)], as was its titer [median (IQR) 485 (92-922) vs 79 [33-180] IU/mL]. Anti-receptor binding domain and anti-spike S2 IgG levels were associated with IBD status. We found an association between anti-spike S2 IgG levels and time since vaccination (β -4.85, 95% CI -7.14 to 2.71, P = 0.0001), history of SARS-CoV-2 polymerase chain reaction positivity (206.76, 95% CI 39.93-374.05, P = 0.0213), and anti-tumor necrosis factor treatment (-239.68, 95% CI -396.44-83.55, P = 0.0047). Forty-three percent of patients reported vaccination side effects (mostly mild). Forty-six percent of observations with positive anti-nucleocapsid IgG had a history of SARS-CoV-2 infection | ||
520 | |a CONCLUSIONS: Patients with IBD produced higher levels of postvaccination anti-spike S2 antibodies than controls. Previous SARS-CoV-2 infection is associated with higher production of postvaccination antibodies and anti-tumor necrosis factor treatment with lower production | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Research Support, Non-U.S. Gov't | |
650 | 7 | |a Antibodies, Viral |2 NLM | |
650 | 7 | |a BNT162 Vaccine |2 NLM | |
650 | 7 | |a COVID-19 Vaccines |2 NLM | |
650 | 7 | |a Immunoglobulin G |2 NLM | |
650 | 7 | |a Tumor Necrosis Factor-alpha |2 NLM | |
700 | 1 | |a Copova, Ivana |e verfasserin |4 aut | |
700 | 1 | |a Durilova, Marianna |e verfasserin |4 aut | |
700 | 1 | |a Kazeka, Denis |e verfasserin |4 aut | |
700 | 1 | |a Kubat, Michal |e verfasserin |4 aut | |
700 | 1 | |a Lerchova, Tereza |e verfasserin |4 aut | |
700 | 1 | |a Vlckova, Eva |e verfasserin |4 aut | |
700 | 1 | |a Mitrova, Katarina |e verfasserin |4 aut | |
700 | 1 | |a Rataj, Michal |e verfasserin |4 aut | |
700 | 1 | |a Klocperk, Adam |e verfasserin |4 aut | |
700 | 1 | |a Sediva, Anna |e verfasserin |4 aut | |
700 | 1 | |a Hradsky, Ondrej |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Journal of pediatric gastroenterology and nutrition |d 1982 |g 76(2023), 2 vom: 01. Feb., Seite e36-e44 |w (DE-627)NLM012621927 |x 1536-4801 |7 nnns |
773 | 1 | 8 | |g volume:76 |g year:2023 |g number:2 |g day:01 |g month:02 |g pages:e36-e44 |
856 | 4 | 0 | |u http://dx.doi.org/10.1097/MPG.0000000000003661 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 76 |j 2023 |e 2 |b 01 |c 02 |h e36-e44 |