Acute Hepatitis of Unknown Origin in Children : Two Cases in a Portuguese Hospital
Several cases of paediatric acute hepatitis of an unknown aetiology have been described in these last few months and in several countries worldwide. We present two patients, a 7-month-old girl and an 8-year-old boy, with gastrointestinal symptoms and lethargy, associated with elevation of transaminase levels. Serologies for hepatitis A-E virus and PCR test to SARS-CoV-2 were all negative. In the first case, an adenovirus serotype C could be isolated in a respiratory sample as well as cytomegalovirus (CMV) in the blood (100 copies/mL). In both children, there was a progressive decrease in the hepatic markers and symptomatic resolution, compatible with a good prognosis, also seen globally in most cases. To date, infection remains the most plausible cause to consider, especially when it is presumed to be linked to adenovirus. Other potential agents and causes are still being evaluated, thus emphasizing the importance of continuous epidemiological surveillance, notification, and detailed study of all hepatitis cases.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2023 |
---|---|
Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:36 |
---|---|
Enthalten in: |
Acta medica portuguesa - 36(2023), 7-8 vom: 03. Juli, Seite 506-510 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Craveiro Costa, Ricardo [VerfasserIn] |
---|
Links: |
---|
Themen: |
Acute Disease |
---|
Anmerkungen: |
Date Completed 12.07.2023 Date Revised 18.07.2023 published: Print-Electronic Citation Status MEDLINE |
---|
doi: |
10.20344/amp.18690 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM352071281 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM352071281 | ||
003 | DE-627 | ||
005 | 20231226052859.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231226s2023 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.20344/amp.18690 |2 doi | |
028 | 5 | 2 | |a pubmed24n1173.xml |
035 | |a (DE-627)NLM352071281 | ||
035 | |a (NLM)36696594 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Craveiro Costa, Ricardo |e verfasserin |4 aut | |
245 | 1 | 0 | |a Acute Hepatitis of Unknown Origin in Children |b Two Cases in a Portuguese Hospital |
264 | 1 | |c 2023 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 12.07.2023 | ||
500 | |a Date Revised 18.07.2023 | ||
500 | |a published: Print-Electronic | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Several cases of paediatric acute hepatitis of an unknown aetiology have been described in these last few months and in several countries worldwide. We present two patients, a 7-month-old girl and an 8-year-old boy, with gastrointestinal symptoms and lethargy, associated with elevation of transaminase levels. Serologies for hepatitis A-E virus and PCR test to SARS-CoV-2 were all negative. In the first case, an adenovirus serotype C could be isolated in a respiratory sample as well as cytomegalovirus (CMV) in the blood (100 copies/mL). In both children, there was a progressive decrease in the hepatic markers and symptomatic resolution, compatible with a good prognosis, also seen globally in most cases. To date, infection remains the most plausible cause to consider, especially when it is presumed to be linked to adenovirus. Other potential agents and causes are still being evaluated, thus emphasizing the importance of continuous epidemiological surveillance, notification, and detailed study of all hepatitis cases | ||
650 | 4 | |a Case Reports | |
650 | 4 | |a Journal Article | |
650 | 4 | |a Acute Disease | |
650 | 4 | |a Child | |
650 | 4 | |a Disease Outbreaks | |
650 | 4 | |a Hepatitis | |
650 | 4 | |a Portugal | |
700 | 1 | |a Schrempp Esteves, Catarina |e verfasserin |4 aut | |
700 | 1 | |a Flores, Pedro |e verfasserin |4 aut | |
700 | 1 | |a Varandas, Luís |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Acta medica portuguesa |d 1993 |g 36(2023), 7-8 vom: 03. Juli, Seite 506-510 |w (DE-627)NLM000463329 |x 1646-0758 |7 nnns |
773 | 1 | 8 | |g volume:36 |g year:2023 |g number:7-8 |g day:03 |g month:07 |g pages:506-510 |
856 | 4 | 0 | |u http://dx.doi.org/10.20344/amp.18690 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 36 |j 2023 |e 7-8 |b 03 |c 07 |h 506-510 |