Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients : A double-blind, randomized, placebo-controlled clinical trial
Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved..
Vitamin K deficiency is common among kidney transplant recipients (KTRs) and likely contributes to progressive vascular calcification and stiffness. In this single-center, randomized, double-blind, placebo-controlled trial, we aimed to investigate the effects of vitamin K supplementation on the primary end point, serum calcification propensity (calciprotein particle maturation time, T50), and secondary end points arterial stiffness (pulse wave velocity [PWV]) and vitamin K status in 40 vitamin K-deficient KTRs (plasma dephosphorylated uncarboxylated matrix Gla protein [dp-ucMGP] ≥500 pmol/L). Participants (35% female; age, 57 ± 13 years) were randomized 1:1 to vitamin K2 (menaquinone-7, 360 μg/day) or placebo for 12 weeks. Vitamin K supplementation had no effect on calcification propensity (change in T50 vs baseline +2.3 ± 27.4 minutes) compared with placebo (+0.8 ± 34.4 minutes; Pbetween group = .88) but prevented progression of PWV (change vs baseline -0.06 ± 0.26 m/s) compared with placebo (+0.27 ± 0.43 m/s; Pbetween group = .010). Vitamin K supplementation strongly improved vitamin K status (change in dp-ucMGP vs baseline -385 [-631 to -269] pmol/L) compared with placebo (+39 [-188 to +183] pmol/L; Pbetween group < .001), although most patients remained vitamin K-deficient. In conclusion, vitamin K supplementation did not alter serum calcification propensity but prevented progression of arterial stiffness, suggesting that vitamin K has vascular effects independent of calciprotein particles. These results set the stage for longer-term intervention studies with vitamin K supplementation in KTRs. TRIAL REGISTRY: EU Clinical Trials Register (EudraCT Number: 2019-004906-88) and the Dutch Trial Register (NTR number: NL7687).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:23 |
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| Enthalten in: |
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 23(2023), 4 vom: 24. Apr., Seite 520-530 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Eelderink, Coby [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 10.04.2023 Date Revised 17.04.2023 published: Print-Electronic EudraCT: 2019-004906-88 NTR: NL7687 Citation Status MEDLINE |
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| doi: |
10.1016/j.ajt.2022.12.015 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 100 | 1 | |a Eelderink, Coby |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Effect of vitamin K supplementation on serum calcification propensity and arterial stiffness in vitamin K-deficient kidney transplant recipients |b A double-blind, randomized, placebo-controlled clinical trial |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 10.04.2023 | ||
| 500 | |a Date Revised 17.04.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a EudraCT: 2019-004906-88 | ||
| 500 | |a NTR: NL7687 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 American Society of Transplantation & American Society of Transplant Surgeons. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a Vitamin K deficiency is common among kidney transplant recipients (KTRs) and likely contributes to progressive vascular calcification and stiffness. In this single-center, randomized, double-blind, placebo-controlled trial, we aimed to investigate the effects of vitamin K supplementation on the primary end point, serum calcification propensity (calciprotein particle maturation time, T50), and secondary end points arterial stiffness (pulse wave velocity [PWV]) and vitamin K status in 40 vitamin K-deficient KTRs (plasma dephosphorylated uncarboxylated matrix Gla protein [dp-ucMGP] ≥500 pmol/L). Participants (35% female; age, 57 ± 13 years) were randomized 1:1 to vitamin K2 (menaquinone-7, 360 μg/day) or placebo for 12 weeks. Vitamin K supplementation had no effect on calcification propensity (change in T50 vs baseline +2.3 ± 27.4 minutes) compared with placebo (+0.8 ± 34.4 minutes; Pbetween group = .88) but prevented progression of PWV (change vs baseline -0.06 ± 0.26 m/s) compared with placebo (+0.27 ± 0.43 m/s; Pbetween group = .010). Vitamin K supplementation strongly improved vitamin K status (change in dp-ucMGP vs baseline -385 [-631 to -269] pmol/L) compared with placebo (+39 [-188 to +183] pmol/L; Pbetween group < .001), although most patients remained vitamin K-deficient. In conclusion, vitamin K supplementation did not alter serum calcification propensity but prevented progression of arterial stiffness, suggesting that vitamin K has vascular effects independent of calciprotein particles. These results set the stage for longer-term intervention studies with vitamin K supplementation in KTRs. TRIAL REGISTRY: EU Clinical Trials Register (EudraCT Number: 2019-004906-88) and the Dutch Trial Register (NTR number: NL7687) | ||
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a arterial stiffness | |
| 650 | 4 | |a calcification propensity | |
| 650 | 4 | |a cardiovascular disease | |
| 650 | 4 | |a clinical research/practice | |
| 650 | 4 | |a kidney transplantation/nephrology | |
| 650 | 4 | |a nutrition | |
| 650 | 4 | |a vascular biology | |
| 650 | 4 | |a vascular health | |
| 650 | 4 | |a vitamin K | |
| 650 | 7 | |a Vitamin K |2 NLM | |
| 650 | 7 | |a 12001-79-5 |2 NLM | |
| 650 | 7 | |a Vitamin K 2 |2 NLM | |
| 650 | 7 | |a 11032-49-8 |2 NLM | |
| 700 | 1 | |a Kremer, Daan |e verfasserin |4 aut | |
| 700 | 1 | |a Riphagen, Ineke J |e verfasserin |4 aut | |
| 700 | 1 | |a Knobbe, Tim J |e verfasserin |4 aut | |
| 700 | 1 | |a Schurgers, Leon J |e verfasserin |4 aut | |
| 700 | 1 | |a Pasch, Andreas |e verfasserin |4 aut | |
| 700 | 1 | |a Mulder, D J |e verfasserin |4 aut | |
| 700 | 1 | |a Corpeleijn, Eva |e verfasserin |4 aut | |
| 700 | 1 | |a Navis, Gerjan |e verfasserin |4 aut | |
| 700 | 1 | |a Bakker, Stephan J L |e verfasserin |4 aut | |
| 700 | 1 | |a de Borst, Martin H |e verfasserin |4 aut | |
| 700 | 1 | |a Te Velde-Keyzer, Charlotte A |e verfasserin |4 aut | |
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