Antidepressants can induce mutation and enhance persistence toward multiple antibiotics
Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While antibiotics are acknowledged as the major driver of increasing antibiotic resistance, little attention is paid to the contribution of antidepressants in this process. Here, we demonstrate that antidepressants at clinically relevant concentrations induce resistance to multiple antibiotics, even following short periods of exposure. Antibiotic persistence was also enhanced. Phenotypic and genotypic analyses revealed the enhanced production of reactive oxygen species following exposure to antidepressants was directly associated with increased resistance. An enhanced stress signature response and stimulation of efflux pump expression were also associated with increased resistance and persistence. Mathematical modeling also predicted that antidepressants would accelerate the emergence of antibiotic-resistant bacteria, and persister cells would help to maintain the resistance. Overall, our findings highlight the antibiotic resistance risk caused by antidepressants.
| Errataetall: |
CommentIn: J Urol. 2023 Jun;209(6):1215-1216. - PMID 36946101 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:120 |
|---|---|
| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 120(2023), 5 vom: 31. Jan., Seite e2208344120 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Wang, Yue [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Anti-Bacterial Agents |
|---|
| Anmerkungen: |
Date Completed 25.01.2023 Date Revised 16.11.2023 published: Print-Electronic CommentIn: J Urol. 2023 Jun;209(6):1215-1216. - PMID 36946101 Citation Status MEDLINE |
|---|
| doi: |
10.1073/pnas.2208344120 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM352003472 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM352003472 | ||
| 003 | DE-627 | ||
| 005 | 20231226052730.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1073/pnas.2208344120 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1173.xml |
| 035 | |a (DE-627)NLM352003472 | ||
| 035 | |a (NLM)36689653 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Wang, Yue |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Antidepressants can induce mutation and enhance persistence toward multiple antibiotics |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 25.01.2023 | ||
| 500 | |a Date Revised 16.11.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: J Urol. 2023 Jun;209(6):1215-1216. - PMID 36946101 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Antibiotic resistance is an urgent threat to global health. Antidepressants are consumed in large quantities, with a similar pharmaceutical market share (4.8%) to antibiotics (5%). While antibiotics are acknowledged as the major driver of increasing antibiotic resistance, little attention is paid to the contribution of antidepressants in this process. Here, we demonstrate that antidepressants at clinically relevant concentrations induce resistance to multiple antibiotics, even following short periods of exposure. Antibiotic persistence was also enhanced. Phenotypic and genotypic analyses revealed the enhanced production of reactive oxygen species following exposure to antidepressants was directly associated with increased resistance. An enhanced stress signature response and stimulation of efflux pump expression were also associated with increased resistance and persistence. Mathematical modeling also predicted that antidepressants would accelerate the emergence of antibiotic-resistant bacteria, and persister cells would help to maintain the resistance. Overall, our findings highlight the antibiotic resistance risk caused by antidepressants | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a antibiotic resistance | |
| 650 | 4 | |a antidepressants | |
| 650 | 4 | |a mutation | |
| 650 | 4 | |a persistence | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 650 | 7 | |a Antidepressive Agents |2 NLM | |
| 700 | 1 | |a Yu, Zhigang |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Pengbo |e verfasserin |4 aut | |
| 700 | 1 | |a Lu, Ji |e verfasserin |4 aut | |
| 700 | 1 | |a Mao, Likai |e verfasserin |4 aut | |
| 700 | 1 | |a Ngiam, Lyman |e verfasserin |4 aut | |
| 700 | 1 | |a Yuan, Zhiguo |e verfasserin |4 aut | |
| 700 | 1 | |a Engelstädter, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Schembri, Mark A |e verfasserin |4 aut | |
| 700 | 1 | |a Guo, Jianhua |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Proceedings of the National Academy of Sciences of the United States of America |d 1915 |g 120(2023), 5 vom: 31. Jan., Seite e2208344120 |w (DE-627)NLM000008982 |x 1091-6490 |7 nnns |
| 773 | 1 | 8 | |g volume:120 |g year:2023 |g number:5 |g day:31 |g month:01 |g pages:e2208344120 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1073/pnas.2208344120 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 120 |j 2023 |e 5 |b 31 |c 01 |h e2208344120 | ||