Electroencephalography signals and neurodevelopment after Kawasaki disease : A pilot study
© 2023 The Authors. Pediatrics International published by John Wiley & Sons Australia, Ltd on behalf of Japan Pediatric Society..
BACKGROUND: Acute Kawasaki disease (KD) induces central nervous system inflammation and excessive irritability. Long-term impacts on children's neurodevelopment have only been studied marginally. This pilot study aimed to describe the neuropsychological profile of primary school-aged children with a history of KD and to explore the impacts of KD on electroencephalography (EEG) markers associated with attention and brain maturation.
METHODS: Fifteen children (8.8 ± 2.5 years) were recruited 4.9 ± 2.7 years after KD onset. Intellectual abilities, long-term memory, and auditory sustained attention were evaluated. Parents completed standardized questionnaires assessing (1) executive functioning; (2) internalizing and externalizing difficulties; (3) attention deficit hyperactivity disorder symptoms; and (4) autism spectrum disorder symptoms. Theta/beta ratio (TBR) and alpha peak (AP) were extracted from resting-state EEG and compared with 32 controls (8.9 ± 2.1 years). The alpha band was analyzed using a feature reduction algorithm to detect potential groupings.
RESULTS: Performances showed preserved intellectual abilities and memory. Sustained attention performance was within the lower range for 4/14 participants (29%), with considerable parental reports of inattention (43%), working memory difficulties (50%), and hyperactivity-impulsivity (36%). No alterations in the TBR were found but the KD group presented a significantly lower AP amplitude ratio. A clear separation of KD cohort into two clusters showed that acute irritability is associated with a weaker AP.
CONCLUSIONS: Despite overall preserved cognitive functions, there is a possible association between KD and attention deficit concerns. This first EEG-based study indicates alpha peak abnormality after KD, predominantly in children with acute irritability. Longitudinal studies are warranted to better characterize patients' neurodevelopmental trajectory.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:65 |
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| Enthalten in: |
Pediatrics international : official journal of the Japan Pediatric Society - 65(2023), 1 vom: 20. Jan., Seite e15482 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fauteux, Audrey-Ann [VerfasserIn] |
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| Links: |
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| Themen: |
Behavior |
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| Anmerkungen: |
Date Completed 28.04.2023 Date Revised 28.04.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1111/ped.15482 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM351911065 |
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| 100 | 1 | |a Fauteux, Audrey-Ann |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Electroencephalography signals and neurodevelopment after Kawasaki disease |b A pilot study |
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| 500 | |a Date Revised 28.04.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Pediatrics International published by John Wiley & Sons Australia, Ltd on behalf of Japan Pediatric Society. | ||
| 520 | |a BACKGROUND: Acute Kawasaki disease (KD) induces central nervous system inflammation and excessive irritability. Long-term impacts on children's neurodevelopment have only been studied marginally. This pilot study aimed to describe the neuropsychological profile of primary school-aged children with a history of KD and to explore the impacts of KD on electroencephalography (EEG) markers associated with attention and brain maturation | ||
| 520 | |a METHODS: Fifteen children (8.8 ± 2.5 years) were recruited 4.9 ± 2.7 years after KD onset. Intellectual abilities, long-term memory, and auditory sustained attention were evaluated. Parents completed standardized questionnaires assessing (1) executive functioning; (2) internalizing and externalizing difficulties; (3) attention deficit hyperactivity disorder symptoms; and (4) autism spectrum disorder symptoms. Theta/beta ratio (TBR) and alpha peak (AP) were extracted from resting-state EEG and compared with 32 controls (8.9 ± 2.1 years). The alpha band was analyzed using a feature reduction algorithm to detect potential groupings | ||
| 520 | |a RESULTS: Performances showed preserved intellectual abilities and memory. Sustained attention performance was within the lower range for 4/14 participants (29%), with considerable parental reports of inattention (43%), working memory difficulties (50%), and hyperactivity-impulsivity (36%). No alterations in the TBR were found but the KD group presented a significantly lower AP amplitude ratio. A clear separation of KD cohort into two clusters showed that acute irritability is associated with a weaker AP | ||
| 520 | |a CONCLUSIONS: Despite overall preserved cognitive functions, there is a possible association between KD and attention deficit concerns. This first EEG-based study indicates alpha peak abnormality after KD, predominantly in children with acute irritability. Longitudinal studies are warranted to better characterize patients' neurodevelopmental trajectory | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Kawasaki disease | |
| 650 | 4 | |a behavior | |
| 650 | 4 | |a cognition | |
| 650 | 4 | |a electroencephalography | |
| 650 | 4 | |a neurodevelopment | |
| 700 | 1 | |a Gutierrez Rojas, Rocio |e verfasserin |4 aut | |
| 700 | 1 | |a Agbogba, Kristian |e verfasserin |4 aut | |
| 700 | 1 | |a Benovoy, Mitchel |e verfasserin |4 aut | |
| 700 | 1 | |a Charlebois-Poirier, Audrey-Rose |e verfasserin |4 aut | |
| 700 | 1 | |a Lalancette, Eve |e verfasserin |4 aut | |
| 700 | 1 | |a Lippé, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Dahdah, Nagib |e verfasserin |4 aut | |
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