Long-Term Tailor-Made Exercise Intervention Reduces the Risk of Developing Cardiovascular Diseases and All-Cause Mortality in Patients with Diabetic Kidney Disease
This study aimed to determine the effect of long-term exercise on the risk of developing cardiovascular diseases (CVD) and all-cause mortality in patients with diabetic kidney disease (DKD). A single-center, prospective intervention study using propensity score matching was performed over 24 months. The intervention group (n = 67) received six months of individual exercise instruction from a physical therapist, who performed aerobic and muscle-strengthening exercises under unsupervised conditions. New events were defined as the composite endpoint of stroke or CVD requiring hospitalization, initiation of hemodialysis or peritoneal dialysis, or all-cause mortality. The cumulative survival rate without new events at 24 months was significantly higher in the intervention group (0.881, p = 0.016) than in the control group (n = 67, 0.715). Two-way analysis of variance revealed a significant effect of the group factor on high density lipoprotein-cholesterol (HDL-C) which was higher in the intervention group than in the control group (p = 0.004); eGFRcr showed a significant effect of the time factor, which was lower at 24 months than before intervention (p = 0.043). No interactions were observed for all items. In conclusion, aerobic exercises combined with upper and lower limb muscle strengthening for six months reduce the risk of developing CVD and all-cause mortality in patients with DKD.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Journal of clinical medicine - 12(2023), 2 vom: 15. Jan. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tamiya, Hajime [VerfasserIn] |
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| Links: |
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| Themen: |
Cardiovascular events |
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| Anmerkungen: |
Date Revised 01.02.2023 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.3390/jcm12020691 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351863400 |
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| 520 | |a This study aimed to determine the effect of long-term exercise on the risk of developing cardiovascular diseases (CVD) and all-cause mortality in patients with diabetic kidney disease (DKD). A single-center, prospective intervention study using propensity score matching was performed over 24 months. The intervention group (n = 67) received six months of individual exercise instruction from a physical therapist, who performed aerobic and muscle-strengthening exercises under unsupervised conditions. New events were defined as the composite endpoint of stroke or CVD requiring hospitalization, initiation of hemodialysis or peritoneal dialysis, or all-cause mortality. The cumulative survival rate without new events at 24 months was significantly higher in the intervention group (0.881, p = 0.016) than in the control group (n = 67, 0.715). Two-way analysis of variance revealed a significant effect of the group factor on high density lipoprotein-cholesterol (HDL-C) which was higher in the intervention group than in the control group (p = 0.004); eGFRcr showed a significant effect of the time factor, which was lower at 24 months than before intervention (p = 0.043). No interactions were observed for all items. In conclusion, aerobic exercises combined with upper and lower limb muscle strengthening for six months reduce the risk of developing CVD and all-cause mortality in patients with DKD | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a diabetes mellitus | |
| 650 | 4 | |a diabetic kidney disease | |
| 650 | 4 | |a exercise | |
| 650 | 4 | |a physical therapist | |
| 700 | 1 | |a Tamura, Yuma |e verfasserin |4 aut | |
| 700 | 1 | |a Nagashima, Yasuko |e verfasserin |4 aut | |
| 700 | 1 | |a Tsurumi, Tomoki |e verfasserin |4 aut | |
| 700 | 1 | |a Terashima, Masato |e verfasserin |4 aut | |
| 700 | 1 | |a Ochiai, Kaori |e verfasserin |4 aut | |
| 700 | 1 | |a Ehara, Kyosuke |e verfasserin |4 aut | |
| 700 | 1 | |a Furuya, Tomoki |e verfasserin |4 aut | |
| 700 | 1 | |a Banba, Nobuyuki |e verfasserin |4 aut | |
| 700 | 1 | |a Nakatani, Yuki |e verfasserin |4 aut | |
| 700 | 1 | |a Hoshiai, Megumi |e verfasserin |4 aut | |
| 700 | 1 | |a Ueno, Asuka |e verfasserin |4 aut | |
| 700 | 1 | |a Tomoe, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Kawabe, Atsuhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Sugiyama, Takushi |e verfasserin |4 aut | |
| 700 | 1 | |a Kawamoto, Shinya |e verfasserin |4 aut | |
| 700 | 1 | |a Yasu, Takanori |e verfasserin |4 aut | |
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