Pollutant-induced pyroptosis in humans and other animals
Copyright © 2023 Elsevier Inc. All rights reserved..
Pyroptosis is a form of lytic cell death with pro-inflammatory characteristics, induced upon the activation of certain inflammatory caspases by inflammasome complexes such as NLRP3 inflammasome. Gasdermin proteins as the mediators of pyroptosis form cell membrane pores upon activation, which release certain cellular contents into the extracellular space including inflammatory cytokines such as IL-1β and IL-18, and also damage the integrity of the cell membrane. Gasdermins have been implicated in autoimmune and inflammatory diseases, infectious diseases, deafness and cancer. Mostly in the last 2 years, diverse pollutant types including particulate matter, cadmium and polystyrene microplastics were reported to induce pyroptotic cell death in diverse tissues from mammals to birds. In the present study, we review our current understanding of pollutant-induced pyroptosis as well as current knowledge of upstream events leading to pyroptotic cell death upon exposure to pollutants.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:316 |
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Enthalten in: |
Life sciences - 316(2023) vom: 01. März, Seite 121386 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Berkel, Caglar [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 14.02.2023 Date Revised 14.02.2023 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1016/j.lfs.2023.121386 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM351683992 |
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520 | |a Pyroptosis is a form of lytic cell death with pro-inflammatory characteristics, induced upon the activation of certain inflammatory caspases by inflammasome complexes such as NLRP3 inflammasome. Gasdermin proteins as the mediators of pyroptosis form cell membrane pores upon activation, which release certain cellular contents into the extracellular space including inflammatory cytokines such as IL-1β and IL-18, and also damage the integrity of the cell membrane. Gasdermins have been implicated in autoimmune and inflammatory diseases, infectious diseases, deafness and cancer. Mostly in the last 2 years, diverse pollutant types including particulate matter, cadmium and polystyrene microplastics were reported to induce pyroptotic cell death in diverse tissues from mammals to birds. In the present study, we review our current understanding of pollutant-induced pyroptosis as well as current knowledge of upstream events leading to pyroptotic cell death upon exposure to pollutants | ||
650 | 4 | |a Journal Article | |
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