Alterations in smell or taste in individuals infected with SARS-CoV-2 during periods of Omicron variant dominance
Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved..
OBJECTIVES: To characterize the prevalence, severity, correlation with initial symptoms, and role of vaccination in patients with COVID-19 with smell or taste alterations (STAs).
METHODS: We conducted an observational study of patients infected with SARS-CoV-2 Omicron admitted to three hospitals between May 17 and June 16, 2022. The olfactory and gustatory functions were evaluated using the taste and smell survey and the numerical visual analog scale at two time points.
RESULTS: The T1 and T2 time point assessments were completed by 688 and 385 participants, respectively. The prevalence of STAs at two time points was 41.3% vs 42.6%. Furthermore, no difference existed in the severity distribution of taste and smell survey, smell, or taste visual analog scale scores between the groups. Patients with initial symptoms of headache (P = 0.03) and muscle pain (P = 0.04) were more likely to develop STAs, whereas higher education; three-dose vaccination; no symptoms yet; or initial symptoms of cough, throat discomfort, and fever demonstrated protective effects, and the results were statistically significant.
CONCLUSION: The prevalence of STAs did not decrease significantly during the Omicron dominance, but the severity was reduced, and vaccination demonstrated a protective effect. In addition, the findings suggest that the presence of STAs is likely to be an important indicator of viral invasion of the nervous system.
| Errataetall: |
CommentIn: Int J Infect Dis. 2023 Apr;129:205-206. - PMID 36805326 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:128 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 128(2023) vom: 01. März, Seite 278-284 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Jian [VerfasserIn] |
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| Links: |
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| Themen: |
Anosmia |
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| Anmerkungen: |
Date Completed 27.02.2023 Date Revised 03.07.2023 published: Print-Electronic CommentIn: Int J Infect Dis. 2023 Apr;129:205-206. - PMID 36805326 Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2023.01.017 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351682775 |
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| 100 | 1 | |a Song, Jian |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Alterations in smell or taste in individuals infected with SARS-CoV-2 during periods of Omicron variant dominance |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Completed 27.02.2023 | ||
| 500 | |a Date Revised 03.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Int J Infect Dis. 2023 Apr;129:205-206. - PMID 36805326 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a OBJECTIVES: To characterize the prevalence, severity, correlation with initial symptoms, and role of vaccination in patients with COVID-19 with smell or taste alterations (STAs) | ||
| 520 | |a METHODS: We conducted an observational study of patients infected with SARS-CoV-2 Omicron admitted to three hospitals between May 17 and June 16, 2022. The olfactory and gustatory functions were evaluated using the taste and smell survey and the numerical visual analog scale at two time points | ||
| 520 | |a RESULTS: The T1 and T2 time point assessments were completed by 688 and 385 participants, respectively. The prevalence of STAs at two time points was 41.3% vs 42.6%. Furthermore, no difference existed in the severity distribution of taste and smell survey, smell, or taste visual analog scale scores between the groups. Patients with initial symptoms of headache (P = 0.03) and muscle pain (P = 0.04) were more likely to develop STAs, whereas higher education; three-dose vaccination; no symptoms yet; or initial symptoms of cough, throat discomfort, and fever demonstrated protective effects, and the results were statistically significant | ||
| 520 | |a CONCLUSION: The prevalence of STAs did not decrease significantly during the Omicron dominance, but the severity was reduced, and vaccination demonstrated a protective effect. In addition, the findings suggest that the presence of STAs is likely to be an important indicator of viral invasion of the nervous system | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Anosmia | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Dysgeusia | |
| 650 | 4 | |a Olfactory and gustatory dysfunction | |
| 650 | 4 | |a SARS-CoV-2 | |
| 700 | 1 | |a Jing, Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Zhu, Enzhao |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Qidong |e verfasserin |4 aut | |
| 700 | 1 | |a Fei, Miaomiao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Hui |e verfasserin |4 aut | |
| 700 | 1 | |a An, Guanghui |e verfasserin |4 aut | |
| 700 | 1 | |a Cao, Silu |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Jinxuan |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Guanghui |e verfasserin |4 aut | |
| 700 | 1 | |a Liu, Yi |e verfasserin |4 aut | |
| 700 | 1 | |a Ai, Zisheng |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, Yingna |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Cheng |e verfasserin |4 aut | |
| 700 | 1 | |a Xiong, Lize |e verfasserin |4 aut | |
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