Regional variations distinguish auditory from visual evoked potentials in healthy 4 week old piglets
Creative Commons Attribution license..
Objective.Evoked potentials (EP), measured using electroencephalographic (EEG) recordings provide an opportunity to monitor cognitive dysfunctions after neurological diseases or traumatic brain injury (TBI). The 4 week old piglet is an established model of paediatric TBI; therefore, healthy piglets were studied to establish feasibility of obtaining responses to auditory and visual stimuli. A secondary aim was to input the EEG data into a piglet computational model to localize the brain sources related to processing. We tested the hypotheses: (1) visual, auditory-standard, and auditory-target stimuli elicit responses, (2) there is an effect of stimulus type, day tested, and electrode region on EPs from EEG, (3) there is an effect of stimulus type, day tested, and brain region on localized sources from a computational model.Approach.Eleven 4 week old female piglets were fitted with a 32-electrode net and presented with a simple white light stimulus and an auditory oddball click train (70 standard; 30 target tones).Main results.N1 andP2 amplitudes were consistently observed for all stimulus types. Significant interaction effects between brain region and stimulus for EP and current density demonstrate that cognitive responses are specific to each modality with auditory localizing to the temporal region and visual to the occipital regions. There was a day effect where larger responses were found on the first day than day 2 and 3 and may be due to the novelty of the stimulus on the first day. Visual stimuli had largerP1 amplitudes and earlier latencies (P1,N1) than auditory which coincides with current density results at 50 ms where larger activations were observed for visual. At 85 ms, auditory had significantly larger current densities coincident with larger and longerN1 amplitudes and latencies than visual.Significance.Auditory and visual processing were successfully and consistently obtained in a porcine model and can be evaluated as a diagnostic assessment for TBI.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:44 |
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| Enthalten in: |
Physiological measurement - 44(2023), 2 vom: 28. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Oeur, R Anna [VerfasserIn] |
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| Links: |
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| Themen: |
Auditory oddball paradigm |
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| Anmerkungen: |
Date Completed 01.03.2023 Date Revised 05.03.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1088/1361-6579/acb4da |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351679375 |
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| 245 | 1 | 0 | |a Regional variations distinguish auditory from visual evoked potentials in healthy 4 week old piglets |
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| 500 | |a Date Revised 05.03.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Creative Commons Attribution license. | ||
| 520 | |a Objective.Evoked potentials (EP), measured using electroencephalographic (EEG) recordings provide an opportunity to monitor cognitive dysfunctions after neurological diseases or traumatic brain injury (TBI). The 4 week old piglet is an established model of paediatric TBI; therefore, healthy piglets were studied to establish feasibility of obtaining responses to auditory and visual stimuli. A secondary aim was to input the EEG data into a piglet computational model to localize the brain sources related to processing. We tested the hypotheses: (1) visual, auditory-standard, and auditory-target stimuli elicit responses, (2) there is an effect of stimulus type, day tested, and electrode region on EPs from EEG, (3) there is an effect of stimulus type, day tested, and brain region on localized sources from a computational model.Approach.Eleven 4 week old female piglets were fitted with a 32-electrode net and presented with a simple white light stimulus and an auditory oddball click train (70 standard; 30 target tones).Main results.N1 andP2 amplitudes were consistently observed for all stimulus types. Significant interaction effects between brain region and stimulus for EP and current density demonstrate that cognitive responses are specific to each modality with auditory localizing to the temporal region and visual to the occipital regions. There was a day effect where larger responses were found on the first day than day 2 and 3 and may be due to the novelty of the stimulus on the first day. Visual stimuli had largerP1 amplitudes and earlier latencies (P1,N1) than auditory which coincides with current density results at 50 ms where larger activations were observed for visual. At 85 ms, auditory had significantly larger current densities coincident with larger and longerN1 amplitudes and latencies than visual.Significance.Auditory and visual processing were successfully and consistently obtained in a porcine model and can be evaluated as a diagnostic assessment for TBI | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a EEG | |
| 650 | 4 | |a auditory oddball paradigm | |
| 650 | 4 | |a porcine | |
| 650 | 4 | |a source localization | |
| 650 | 4 | |a visual event-related potentials | |
| 700 | 1 | |a Palaniswamy, Maduran |e verfasserin |4 aut | |
| 700 | 1 | |a Ha, Matthew |e verfasserin |4 aut | |
| 700 | 1 | |a Fernandez-Corazza, Mariano |e verfasserin |4 aut | |
| 700 | 1 | |a Margulies, Susan S |e verfasserin |4 aut | |
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