In vivoestimation of anisotropic mechanical properties of the gastrocnemius during functional loading with MR elastography
© 2023 Institute of Physics and Engineering in Medicine..
Objective.In vivoimaging assessments of skeletal muscle structure and function allow for longitudinal quantification of tissue health. Magnetic resonance elastography (MRE) non-invasively quantifies tissue mechanical properties, allowing for evaluation of skeletal muscle biomechanics in response to loading, creating a better understanding of muscle functional health.Approach. In this study, we analyze the anisotropic mechanical response of calf muscles using MRE with a transversely isotropic, nonlinear inversion algorithm (TI-NLI) to investigate the role of muscle fiber stiffening under load. We estimate anisotropic material parameters including fiber shear stiffness (μ1), substrate shear stiffness (μ2), shear anisotropy (ϕ), and tensile anisotropy (ζ) of the gastrocnemius muscle in response to both passive and active tension.Main results. In passive tension, we found a significant increase inμ1,ϕ,andζwith increasing muscle length. While in active tension, we observed increasingμ2and decreasingϕandζduring active dorsiflexion and plantarflexion-indicating less anisotropy-with greater effects when the muscles act as agonist.Significance. The study demonstrates the ability of this anisotropic MRE method to capture the multifaceted mechanical response of skeletal muscle to tissue loading from muscle lengthening and contraction.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:68 |
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| Enthalten in: |
Physics in medicine and biology - 68(2023), 4 vom: 06. Feb. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Smith, Daniel R [VerfasserIn] |
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| Links: |
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| Themen: |
Gastrocnemius |
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| Anmerkungen: |
Date Completed 07.02.2023 Date Revised 07.02.2024 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1088/1361-6560/acb482 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351635084 |
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| 100 | 1 | |a Smith, Daniel R |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a In vivoestimation of anisotropic mechanical properties of the gastrocnemius during functional loading with MR elastography |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 07.02.2024 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 Institute of Physics and Engineering in Medicine. | ||
| 520 | |a Objective.In vivoimaging assessments of skeletal muscle structure and function allow for longitudinal quantification of tissue health. Magnetic resonance elastography (MRE) non-invasively quantifies tissue mechanical properties, allowing for evaluation of skeletal muscle biomechanics in response to loading, creating a better understanding of muscle functional health.Approach. In this study, we analyze the anisotropic mechanical response of calf muscles using MRE with a transversely isotropic, nonlinear inversion algorithm (TI-NLI) to investigate the role of muscle fiber stiffening under load. We estimate anisotropic material parameters including fiber shear stiffness (μ1), substrate shear stiffness (μ2), shear anisotropy (ϕ), and tensile anisotropy (ζ) of the gastrocnemius muscle in response to both passive and active tension.Main results. In passive tension, we found a significant increase inμ1,ϕ,andζwith increasing muscle length. While in active tension, we observed increasingμ2and decreasingϕandζduring active dorsiflexion and plantarflexion-indicating less anisotropy-with greater effects when the muscles act as agonist.Significance. The study demonstrates the ability of this anisotropic MRE method to capture the multifaceted mechanical response of skeletal muscle to tissue loading from muscle lengthening and contraction | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a gastrocnemius | |
| 650 | 4 | |a magnetic resonance elastography | |
| 650 | 4 | |a skeletal muscle | |
| 650 | 4 | |a stiffness | |
| 650 | 4 | |a tension | |
| 700 | 1 | |a Caban-Rivera, Diego A |e verfasserin |4 aut | |
| 700 | 1 | |a Williams, L Tyler |e verfasserin |4 aut | |
| 700 | 1 | |a Van Houten, Elijah E W |e verfasserin |4 aut | |
| 700 | 1 | |a Bayly, Phil V |e verfasserin |4 aut | |
| 700 | 1 | |a Paulsen, Keith D |e verfasserin |4 aut | |
| 700 | 1 | |a McGarry, Matthew D J |e verfasserin |4 aut | |
| 700 | 1 | |a Johnson, Curtis L |e verfasserin |4 aut | |
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