Wound healing and antibacterial capability of electrospun polyurethane nanofibers incorporating Calendula officinalis and Propolis extracts
In order to produce a healing accelerator antibacterial wound dressing, different electrospun polyurethane (PU)-based nanofibers inclusive Calendula officinalis and Propolis ethanolic extracts were fabricated. The measurement of minimum inhibitory concentrations (MIC) against Methicillin-resistant Staphylococcus aureus (MRSA) determined the concentrations of incorporating extracts. Then the morphological properties of the produced polyurethane (PU), polyurethane/C. officinalis (PU/CO), polyurethane/Propolis (PU/PR), polyurethane/C. officinalis/Propolis (PU/CO/PR) were analyzed by scanning electron microscopy (SEM). The physicochemical features and biological characteristics of the fabricated nanofibers were evaluated. Subsequently, the antibacterial and wound-healing efficiency of electrospun wound dressings were tested under in vivo situation. The electrospun PU/CO/PR nanofiber illustrated the most degree of antibacterial, antioxidant, and cell proliferation efficiencies. In vivo examination and histological analysis confirmed significant improvement in the complete, well-organized wound-healing process in MRSA-infected wounds treated with PU/CO/PR. These outcomes described PU/CO/PR electrospun nanofibers as a wound dressing that can significantly facilitate wound healing with notable antibacterial, antioxidant, and cell proliferation properties.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Journal of biomaterials science. Polymer edition - 34(2023), 11 vom: 18. Aug., Seite 1491-1516 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Davoudabadi, Masoud [VerfasserIn] |
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| Links: |
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| Themen: |
9009-62-5 |
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| Anmerkungen: |
Date Completed 31.07.2023 Date Revised 31.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/09205063.2023.2170138 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351592946 |
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| 245 | 1 | 0 | |a Wound healing and antibacterial capability of electrospun polyurethane nanofibers incorporating Calendula officinalis and Propolis extracts |
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| 500 | |a Date Completed 31.07.2023 | ||
| 500 | |a Date Revised 31.07.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a In order to produce a healing accelerator antibacterial wound dressing, different electrospun polyurethane (PU)-based nanofibers inclusive Calendula officinalis and Propolis ethanolic extracts were fabricated. The measurement of minimum inhibitory concentrations (MIC) against Methicillin-resistant Staphylococcus aureus (MRSA) determined the concentrations of incorporating extracts. Then the morphological properties of the produced polyurethane (PU), polyurethane/C. officinalis (PU/CO), polyurethane/Propolis (PU/PR), polyurethane/C. officinalis/Propolis (PU/CO/PR) were analyzed by scanning electron microscopy (SEM). The physicochemical features and biological characteristics of the fabricated nanofibers were evaluated. Subsequently, the antibacterial and wound-healing efficiency of electrospun wound dressings were tested under in vivo situation. The electrospun PU/CO/PR nanofiber illustrated the most degree of antibacterial, antioxidant, and cell proliferation efficiencies. In vivo examination and histological analysis confirmed significant improvement in the complete, well-organized wound-healing process in MRSA-infected wounds treated with PU/CO/PR. These outcomes described PU/CO/PR electrospun nanofibers as a wound dressing that can significantly facilitate wound healing with notable antibacterial, antioxidant, and cell proliferation properties | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Calendula officinalis | |
| 650 | 4 | |a Electrospinning | |
| 650 | 4 | |a Propolis extracts | |
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