Key hepatoprotective roles of mitochondria in liver regeneration
Treatment of advanced liver disease using surgical modalities is possible due to the liver's innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating their crucial roles in liver regeneration. Mitochondria enable the regenerating liver to meet massive metabolic demands by coordinating energy production to drive cellular proliferative processes and vital homeostatic functions. Mitochondria are also involved in terminating the regenerative process by mediating apoptosis. Studies have shown that attenuation of mitochondrial activity results in delayed liver regeneration, and liver failure following resection is associated with mitochondrial dysfunction. Emerging mitochondria therapy (i.e., mitotherapy) strategies involve isolating healthy donor mitochondria for transplantation into diseased organs to promote regeneration. This review highlights mitochondria's inherent role in liver regeneration.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:324 |
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| Enthalten in: |
American journal of physiology. Gastrointestinal and liver physiology - 324(2023), 3 vom: 01. März, Seite G207-G218 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Lamanilao, Gene G [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 02.03.2023 Date Revised 02.03.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1152/ajpgi.00220.2022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Treatment of advanced liver disease using surgical modalities is possible due to the liver's innate ability to regenerate following resection. Several key cellular events in the regenerative process converge at the mitochondria, implicating their crucial roles in liver regeneration. Mitochondria enable the regenerating liver to meet massive metabolic demands by coordinating energy production to drive cellular proliferative processes and vital homeostatic functions. Mitochondria are also involved in terminating the regenerative process by mediating apoptosis. Studies have shown that attenuation of mitochondrial activity results in delayed liver regeneration, and liver failure following resection is associated with mitochondrial dysfunction. Emerging mitochondria therapy (i.e., mitotherapy) strategies involve isolating healthy donor mitochondria for transplantation into diseased organs to promote regeneration. This review highlights mitochondria's inherent role in liver regeneration | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a liver regeneration | |
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| 650 | 4 | |a mitochondrial bioenergetics | |
| 650 | 4 | |a mitochondrial therapy | |
| 650 | 4 | |a partial hepatectomy | |
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| 700 | 1 | |a Patel, Prisha S |e verfasserin |4 aut | |
| 700 | 1 | |a Azim, Shafquat |e verfasserin |4 aut | |
| 700 | 1 | |a Patel, Disha S |e verfasserin |4 aut | |
| 700 | 1 | |a Bhattacharya, Syamal K |e verfasserin |4 aut | |
| 700 | 1 | |a Eason, James D |e verfasserin |4 aut | |
| 700 | 1 | |a Kuscu, Canan |e verfasserin |4 aut | |
| 700 | 1 | |a Kuscu, Cem |e verfasserin |4 aut | |
| 700 | 1 | |a Bajwa, Amandeep |e verfasserin |4 aut | |
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