Pathways and Mechanisms of Periodontitis Contributing to Adverse Pregnancy Outcomes
Copyright© by Editorial Board of Journal of Sichuan University (Medical Sciences)..
Periodontitis is a chronic oral inflammatory disease with a high incidence in the global population. Periodontal pathogens can colonize and infect multiple human tissues and organs through blood transmission, which is an important risk factor of many systemic diseases. Recently, the correlation between periodontitis and adverse pregnancy outcomes (APOs) has attracted growing research interest. Herein, we systematically reviewed the research progress in the relationship between periodontitis and APOs and summarized reported findings on the pathways and mechanisms by which periodontitis contributes to APOs. We also clarified that intrauterine infection caused by oral pathogens transmitted through blood is an important pathway by which periodontitis interferes with pregnancy. In addition, further research focused on the discovery of more APOs-related oral pathogenic bacteria and their virulence factors, analysis of the interaction between pathogenic bacteria and placental tissue, and pathogenic pathways of oral bacterial invasion of the fetus will promote thorough analysis of the specific molecular mechanism of how periodontitis affects APOs. Furthermore, the validation of the results of human population-based studies through animal/cell experiments and the translation into effective intervention strategies are of great clinical significance to the prevention and control of the occurrence and development of APOs.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:54 |
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| Enthalten in: |
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition - 54(2023), 1 vom: 31. Jan., Seite 39-48 |
| Sprache: |
Chinesisch |
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| Beteiligte Personen: |
Guan, Zhi-Wei [VerfasserIn] |
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| Links: |
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| Themen: |
Adverse pregnancy outcome |
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| Anmerkungen: |
Date Completed 18.01.2023 Date Revised 29.08.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.12182/20230160501 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 520 | |a Periodontitis is a chronic oral inflammatory disease with a high incidence in the global population. Periodontal pathogens can colonize and infect multiple human tissues and organs through blood transmission, which is an important risk factor of many systemic diseases. Recently, the correlation between periodontitis and adverse pregnancy outcomes (APOs) has attracted growing research interest. Herein, we systematically reviewed the research progress in the relationship between periodontitis and APOs and summarized reported findings on the pathways and mechanisms by which periodontitis contributes to APOs. We also clarified that intrauterine infection caused by oral pathogens transmitted through blood is an important pathway by which periodontitis interferes with pregnancy. In addition, further research focused on the discovery of more APOs-related oral pathogenic bacteria and their virulence factors, analysis of the interaction between pathogenic bacteria and placental tissue, and pathogenic pathways of oral bacterial invasion of the fetus will promote thorough analysis of the specific molecular mechanism of how periodontitis affects APOs. Furthermore, the validation of the results of human population-based studies through animal/cell experiments and the translation into effective intervention strategies are of great clinical significance to the prevention and control of the occurrence and development of APOs | ||
| 650 | 4 | |a Systematic Review | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Adverse pregnancy outcome | |
| 650 | 4 | |a Fusobacterium nucleatum | |
| 650 | 4 | |a Intrauterine infection | |
| 650 | 4 | |a Periodontal pathogens | |
| 650 | 4 | |a Periodontitis | |
| 700 | 1 | |a Xu, Tian-Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Shen, Song |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Xiao |e verfasserin |4 aut | |
| 700 | 1 | |a Feng, Qiang |e verfasserin |4 aut | |
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