The Free Triiodothyronine/Free Thyroxine Ratio Is Associated with Frailty in Older Adults : A Longitudinal Multisetting Study
Background: Various models have been proposed to predict frailty, including those based on clinical criteria and phenotypes. However, a simple biomarker associated with frailty has been not yet identified. The aim of this study is to evaluate the relationship between free triiodothyronine (fT3)/free thyroxine (fT4) ratio value and the degree of frailty among three different cohorts of older individuals: (1) acutely ill hospitalized patients, (2) nursing-home (NH) residents, and (3) home-dwelling centenarians. Methods: We performed a secondary analysis of de-identified patient-level data from two prospective observational studies on acutely hospitalized older patients (Geriatric Acute Unit [GAU]), and home-dwelling centenarians (CENT), and a retrospective-prospective observational study on older NH residents. Demographic characteristics, along with a 30-items Frailty Index (FI) and serum thyrotropin, fT3 and fT4 measurements were obtained. Results: Six hundred fifteen individuals (aged 86.4 ± 8.9 years; 55.1% females) were included in the study, including 298 (48.5%) GAU, 250 (40.6%) NH, and 67 (10.9%) CENT. A significant inverse relationship between fT3/fT4 ratio and FI values was observed (ρs = -0.17 [confidence interval; CI: -0.092 to 0.252], p < 0.001), and this was confirmed by logistic multivariate analysis (β = -0.44, odds ratio [OR]: 0.64 [CI: 0.47-0.87], p < 0.001) (after adjustment for age, sex, and cohorts). Moreover, a progressively decreased mortality risk was associated with rising fT3/fT4 ratio (OR 0.60 [CI: 0.44-0.80] β = -0.51, p < 0.001]. Conclusions: The fT3/fT4 ratio value was inversely correlated with frailty degree and mortality risk in a large cohort of older individuals, including centenarians, regardless of their sex and clinical condition. fT3/fT4 ratio value could represent an easily measured independent biochemical marker of frailty degree in older people.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:33 |
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| Enthalten in: |
Thyroid : official journal of the American Thyroid Association - 33(2023), 2 vom: 14. Feb., Seite 169-176 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Okoye, Chukwuma [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 22.02.2023 Date Revised 10.03.2023 published: Print Citation Status MEDLINE |
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| doi: |
10.1089/thy.2022.0422 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351525491 |
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| 100 | 1 | |a Okoye, Chukwuma |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The Free Triiodothyronine/Free Thyroxine Ratio Is Associated with Frailty in Older Adults |b A Longitudinal Multisetting Study |
| 264 | 1 | |c 2023 | |
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| 500 | |a Date Revised 10.03.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Background: Various models have been proposed to predict frailty, including those based on clinical criteria and phenotypes. However, a simple biomarker associated with frailty has been not yet identified. The aim of this study is to evaluate the relationship between free triiodothyronine (fT3)/free thyroxine (fT4) ratio value and the degree of frailty among three different cohorts of older individuals: (1) acutely ill hospitalized patients, (2) nursing-home (NH) residents, and (3) home-dwelling centenarians. Methods: We performed a secondary analysis of de-identified patient-level data from two prospective observational studies on acutely hospitalized older patients (Geriatric Acute Unit [GAU]), and home-dwelling centenarians (CENT), and a retrospective-prospective observational study on older NH residents. Demographic characteristics, along with a 30-items Frailty Index (FI) and serum thyrotropin, fT3 and fT4 measurements were obtained. Results: Six hundred fifteen individuals (aged 86.4 ± 8.9 years; 55.1% females) were included in the study, including 298 (48.5%) GAU, 250 (40.6%) NH, and 67 (10.9%) CENT. A significant inverse relationship between fT3/fT4 ratio and FI values was observed (ρs = -0.17 [confidence interval; CI: -0.092 to 0.252], p < 0.001), and this was confirmed by logistic multivariate analysis (β = -0.44, odds ratio [OR]: 0.64 [CI: 0.47-0.87], p < 0.001) (after adjustment for age, sex, and cohorts). Moreover, a progressively decreased mortality risk was associated with rising fT3/fT4 ratio (OR 0.60 [CI: 0.44-0.80] β = -0.51, p < 0.001]. Conclusions: The fT3/fT4 ratio value was inversely correlated with frailty degree and mortality risk in a large cohort of older individuals, including centenarians, regardless of their sex and clinical condition. fT3/fT4 ratio value could represent an easily measured independent biochemical marker of frailty degree in older people | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Carino, Silvia |e verfasserin |4 aut | |
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| 700 | 1 | |a Franchi, Riccardo |e verfasserin |4 aut | |
| 700 | 1 | |a Rogani, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Cesari, Matteo |e verfasserin |4 aut | |
| 700 | 1 | |a Mari, Daniela |e verfasserin |4 aut | |
| 700 | 1 | |a Vitale, Giovanni |e verfasserin |4 aut | |
| 700 | 1 | |a Malara, Alba |e verfasserin |4 aut | |
| 700 | 1 | |a Calsolaro, Valeria |e verfasserin |4 aut | |
| 700 | 1 | |a Monzani, Fabio |e verfasserin |4 aut | |
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