Cardiovascular outcomes in patients with cancer during a 5-year follow-up : Results from a French administrative database
Copyright © 2023 Elsevier Masson SAS. All rights reserved..
BACKGROUND: Limited data are available regarding the optimal management and prognosis of patients with cancer who develop an acute myocardial infarction.
AIM: The objective of this study was to analyse the characteristics and outcomes of patients according to cancer and myocardial infarction occurrence.
METHODS: Based on the French administrative hospital discharge database, the study collected information for all consecutive patients seen in French hospitals in 2013, excluding those with a history of myocardial infarction. The population was divided into two groups according to their history of cancer. We studied the following outcomes: all-cause and cardiovascular mortality; acute myocardial infarction; and ischaemic stroke. Data were collected after a 5-year follow-up.
RESULTS: Between 2013 and 2019, 3,381,472 patients were seen in French hospitals; among them, 3,323,757 had no history of myocardial infarction. Patients with a history of cancer (n=497,593) had higher incidences of all-cause mortality (17.82%/year vs 3.79%/year), cardiovascular mortality (1.61%/year vs 1.17%/year), myocardial infarction (0.82%/year vs 0.61%/year) and ischaemic stroke (0.91%/year vs 0.62%/year) compared with patients without cancer (n=2,826,164). After performing an adjusted competing-risk analysis, the cumulative incidence of acute myocardial infarction, cardiovascular death and ischaemic stroke incidence was found to be lower in patients with a history of cancer, whereas death of non-cardiac origin was more prevalent in patients with a history of cancer.
CONCLUSIONS: In this observational study, we have shown that patients with cancer have a higher incidence of all-cause mortality, cardiovascular mortality and myocardial infarction. However, multivariable analysis showed a lower cumulative incidence of these events.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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| Enthalten in: |
Archives of cardiovascular diseases - 116(2023), 2 vom: 10. Feb., Seite 88-97 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Boyer, Jérémy [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer |
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| Anmerkungen: |
Date Completed 23.02.2023 Date Revised 23.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.acvd.2022.11.006 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351521542 |
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| 100 | 1 | |a Boyer, Jérémy |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cardiovascular outcomes in patients with cancer during a 5-year follow-up |b Results from a French administrative database |
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| 500 | |a Date Revised 23.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Masson SAS. All rights reserved. | ||
| 520 | |a BACKGROUND: Limited data are available regarding the optimal management and prognosis of patients with cancer who develop an acute myocardial infarction | ||
| 520 | |a AIM: The objective of this study was to analyse the characteristics and outcomes of patients according to cancer and myocardial infarction occurrence | ||
| 520 | |a METHODS: Based on the French administrative hospital discharge database, the study collected information for all consecutive patients seen in French hospitals in 2013, excluding those with a history of myocardial infarction. The population was divided into two groups according to their history of cancer. We studied the following outcomes: all-cause and cardiovascular mortality; acute myocardial infarction; and ischaemic stroke. Data were collected after a 5-year follow-up | ||
| 520 | |a RESULTS: Between 2013 and 2019, 3,381,472 patients were seen in French hospitals; among them, 3,323,757 had no history of myocardial infarction. Patients with a history of cancer (n=497,593) had higher incidences of all-cause mortality (17.82%/year vs 3.79%/year), cardiovascular mortality (1.61%/year vs 1.17%/year), myocardial infarction (0.82%/year vs 0.61%/year) and ischaemic stroke (0.91%/year vs 0.62%/year) compared with patients without cancer (n=2,826,164). After performing an adjusted competing-risk analysis, the cumulative incidence of acute myocardial infarction, cardiovascular death and ischaemic stroke incidence was found to be lower in patients with a history of cancer, whereas death of non-cardiac origin was more prevalent in patients with a history of cancer | ||
| 520 | |a CONCLUSIONS: In this observational study, we have shown that patients with cancer have a higher incidence of all-cause mortality, cardiovascular mortality and myocardial infarction. However, multivariable analysis showed a lower cumulative incidence of these events | ||
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Cardio-oncology | |
| 650 | 4 | |a Coronary artery disease | |
| 650 | 4 | |a Myocardial infarction | |
| 650 | 4 | |a Stroke | |
| 700 | 1 | |a Deharo, Pierre |e verfasserin |4 aut | |
| 700 | 1 | |a Angoulvant, Denis |e verfasserin |4 aut | |
| 700 | 1 | |a Ivanes, Fabrice |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrara, Jerome |e verfasserin |4 aut | |
| 700 | 1 | |a Vaillier, Antoine |e verfasserin |4 aut | |
| 700 | 1 | |a Cautela, Jennifer |e verfasserin |4 aut | |
| 700 | 1 | |a Herbert, Julien |e verfasserin |4 aut | |
| 700 | 1 | |a Saint Etienne, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Cuisset, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Thuny, Franck |e verfasserin |4 aut | |
| 700 | 1 | |a Fauchier, Laurent |e verfasserin |4 aut | |
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