A dermatologic assessment of 101 mpox (monkeypox) cases from 13 countries during the 2022 outbreak : Skin lesion morphology, clinical course, and scarring
Copyright © 2023. Published by Elsevier Inc..
BACKGROUND: In the 2022 mpox (monkeypox) outbreak, 79,000 global cases have been reported. Yet, limited dermatologic data have been published regarding lesion morphology and progression.
OBJECTIVE: The objective of this study was to characterize skin lesion morphology, symptomatology, and outcomes of mpox infection over time.
METHODS: The American Academy of Dermatology/International League of Dermatological Societies Dermatology COVID-19, Mpox, and Emerging Infections Registry captured deidentified patient cases of mpox entered by health care professionals.
RESULTS: From August 4 to November 13, 2022, 101 cases from 13 countries were entered, primarily by dermatologists (92%). Thirty-nine percent had fewer than 5 lesions. In 54% of cases, skin lesions were the first sign of infection. In the first 1-5 days of infection, papules (36%), vesicles (17%), and pustules (20%) predominated. By days 6-10, pustules (36%) were most common, followed by erosions/ulcers (27%) and crusts/scabs (24%). Crusts/scabs were the predominant morphology after day 11. Ten cases of morbilliform rash were reported. Scarring occurred in 13% of the cases.
LIMITATIONS: Registry-reported data cannot address incidence. There is a potential reporting bias from the predilection to report cases with greater clinical severity.
DISCUSSION: These findings highlight differences in skin findings compared to historical outbreaks, notably the presence of skin lesions prior to systemic symptoms and low overall lesion counts. Scarring emerged as a major possible sequela.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:88 |
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| Enthalten in: |
Journal of the American Academy of Dermatology - 88(2023), 5 vom: 31. Mai, Seite 1066-1073 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Prasad, Sonya [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 19.04.2023 Date Revised 13.12.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jaad.2022.12.035 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Prasad, Sonya |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A dermatologic assessment of 101 mpox (monkeypox) cases from 13 countries during the 2022 outbreak |b Skin lesion morphology, clinical course, and scarring |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
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| 500 | |a Date Completed 19.04.2023 | ||
| 500 | |a Date Revised 13.12.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023. Published by Elsevier Inc. | ||
| 520 | |a BACKGROUND: In the 2022 mpox (monkeypox) outbreak, 79,000 global cases have been reported. Yet, limited dermatologic data have been published regarding lesion morphology and progression | ||
| 520 | |a OBJECTIVE: The objective of this study was to characterize skin lesion morphology, symptomatology, and outcomes of mpox infection over time | ||
| 520 | |a METHODS: The American Academy of Dermatology/International League of Dermatological Societies Dermatology COVID-19, Mpox, and Emerging Infections Registry captured deidentified patient cases of mpox entered by health care professionals | ||
| 520 | |a RESULTS: From August 4 to November 13, 2022, 101 cases from 13 countries were entered, primarily by dermatologists (92%). Thirty-nine percent had fewer than 5 lesions. In 54% of cases, skin lesions were the first sign of infection. In the first 1-5 days of infection, papules (36%), vesicles (17%), and pustules (20%) predominated. By days 6-10, pustules (36%) were most common, followed by erosions/ulcers (27%) and crusts/scabs (24%). Crusts/scabs were the predominant morphology after day 11. Ten cases of morbilliform rash were reported. Scarring occurred in 13% of the cases | ||
| 520 | |a LIMITATIONS: Registry-reported data cannot address incidence. There is a potential reporting bias from the predilection to report cases with greater clinical severity | ||
| 520 | |a DISCUSSION: These findings highlight differences in skin findings compared to historical outbreaks, notably the presence of skin lesions prior to systemic symptoms and low overall lesion counts. Scarring emerged as a major possible sequela | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a general dermatology | |
| 650 | 4 | |a global health | |
| 650 | 4 | |a immunocompromised | |
| 650 | 4 | |a infectious disease | |
| 650 | 4 | |a international health | |
| 650 | 4 | |a medical dermatology | |
| 650 | 4 | |a monkeypox | |
| 650 | 4 | |a mpox | |
| 650 | 4 | |a skin lesions | |
| 650 | 4 | |a vaccine | |
| 650 | 4 | |a viral infection | |
| 650 | 4 | |a virus | |
| 700 | 1 | |a Galvan Casas, Cristina |e verfasserin |4 aut | |
| 700 | 1 | |a Strahan, Alexis G |e verfasserin |4 aut | |
| 700 | 1 | |a Fuller, L Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Peebles, Klint |e verfasserin |4 aut | |
| 700 | 1 | |a Carugno, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Leslie, Kieron S |e verfasserin |4 aut | |
| 700 | 1 | |a Harp, Joanna L |e verfasserin |4 aut | |
| 700 | 1 | |a Pumnea, Teodora |e verfasserin |4 aut | |
| 700 | 1 | |a McMahon, Devon E |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenbach, Misha |e verfasserin |4 aut | |
| 700 | 1 | |a Lubov, Janet E |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Geoffrey |e verfasserin |4 aut | |
| 700 | 1 | |a Fox, Lindy P |e verfasserin |4 aut | |
| 700 | 1 | |a McMillen, Allen |e verfasserin |4 aut | |
| 700 | 1 | |a Lim, Henry W |e verfasserin |4 aut | |
| 700 | 1 | |a Stratigos, Alexander J |e verfasserin |4 aut | |
| 700 | 1 | |a Cronin, Terrence A |e verfasserin |4 aut | |
| 700 | 1 | |a Kaufmann, Mark D |e verfasserin |4 aut | |
| 700 | 1 | |a Hruza, George J |e verfasserin |4 aut | |
| 700 | 1 | |a French, Lars E |e verfasserin |4 aut | |
| 700 | 1 | |a Freeman, Esther E |e verfasserin |4 aut | |
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