Atypical Presentations of Extraparenchymal Neurocysticercosis
Copyright © 2023 by North American Neuro-Ophthalmology Society..
BACKGROUND: Neurocysticercosis (NCC) is the most common parasitic infection of the central nervous system and is typically diagnosed through visualization of the cysts in the cerebral parenchyma by neuro-imaging. However, neuro-imaging may not detect extraparenchymal neurocysticercosis (EPNCC), which is a rare manifestation of the disease involving the subarachnoid, meningeal, and intraventricular spaces. We report 2 cases of extraparenchymal neurocysticercosis, and discuss the diagnostic challenges and management of this entity.
METHODS: Two cases were identified through clinical records.
RESULTS: Both patients had an insidious onset with slow progression of disease, and presented with papilledema and cerebrospinal fluid (CSF) eosinophilia. One case was diagnosed with spinal cord biopsy. The other was diagnosed with CSF serology and next-generation sequencing-based pathogen analysis. Both patients were treated with ventriculoperitoneal shunt, systemic antiparasitic agents, and immunosuppression.
CONCLUSIONS: EPNCC is less common than parenchymal NCC. A high level of clinical suspicion is required given its rarity, long incubation period, and slow progression. Diagnosis and treatment can be challenging and requires a multidisciplinary approach.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:43 |
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| Enthalten in: |
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society - 43(2023), 3 vom: 01. Sept., Seite 370-375 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Fan, Jason [VerfasserIn] |
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| Links: |
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| Themen: |
Case Reports |
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| Anmerkungen: |
Date Completed 22.08.2023 Date Revised 02.09.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1097/WNO.0000000000001782 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM351483586 |
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| 245 | 1 | 0 | |a Atypical Presentations of Extraparenchymal Neurocysticercosis |
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| 500 | |a Date Completed 22.08.2023 | ||
| 500 | |a Date Revised 02.09.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 by North American Neuro-Ophthalmology Society. | ||
| 520 | |a BACKGROUND: Neurocysticercosis (NCC) is the most common parasitic infection of the central nervous system and is typically diagnosed through visualization of the cysts in the cerebral parenchyma by neuro-imaging. However, neuro-imaging may not detect extraparenchymal neurocysticercosis (EPNCC), which is a rare manifestation of the disease involving the subarachnoid, meningeal, and intraventricular spaces. We report 2 cases of extraparenchymal neurocysticercosis, and discuss the diagnostic challenges and management of this entity | ||
| 520 | |a METHODS: Two cases were identified through clinical records | ||
| 520 | |a RESULTS: Both patients had an insidious onset with slow progression of disease, and presented with papilledema and cerebrospinal fluid (CSF) eosinophilia. One case was diagnosed with spinal cord biopsy. The other was diagnosed with CSF serology and next-generation sequencing-based pathogen analysis. Both patients were treated with ventriculoperitoneal shunt, systemic antiparasitic agents, and immunosuppression | ||
| 520 | |a CONCLUSIONS: EPNCC is less common than parenchymal NCC. A high level of clinical suspicion is required given its rarity, long incubation period, and slow progression. Diagnosis and treatment can be challenging and requires a multidisciplinary approach | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Tang, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Lily |e verfasserin |4 aut | |
| 700 | 1 | |a Hoang, Phuong T |e verfasserin |4 aut | |
| 700 | 1 | |a Ayoade, Folusakin |e verfasserin |4 aut | |
| 700 | 1 | |a Diaz-Perez, Julio A |e verfasserin |4 aut | |
| 700 | 1 | |a Moss, Heather E |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Hong |e verfasserin |4 aut | |
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