"THE MANTLE" bundle for minimizing cerebral hypoxia in severe traumatic brain injury
© 2023. The Author(s)..
To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential. Cerebral tissue oxygenation represents the balance between oxygen supply and consumption, largely reflecting the adequacy of cerebral perfusion. Multiple physiological parameters determine the oxygen delivered to the brain, including blood pressure, hemoglobin level, systemic oxygenation, microcirculation and many factors are involved in the delivery of oxygen to its final recipient, through the respiratory chain. Brain tissue hypoxia occurs when the supply of oxygen is not adequate or when for some reasons it cannot be used at the cellular level. The causes of hypoxia are variable and can be analyzed pathophysiologically following "the oxygen route." The current trend is precision medicine, individualized and therapeutically directed to the pathophysiology of specific brain damage; however, this requires the availability of multimodal monitoring. For this purpose, we developed the acronym "THE MANTLE," a bundle of therapeutical interventions, which covers and protects the brain, optimizing the components of the oxygen transport system from ambient air to the mitochondria.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:27 |
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| Enthalten in: |
Critical care (London, England) - 27(2023), 1 vom: 12. Jan., Seite 13 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Godoy, Daniel Agustin [VerfasserIn] |
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| Links: |
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| Themen: |
Brain hypoxia |
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| Anmerkungen: |
Date Completed 16.01.2023 Date Revised 17.01.2023 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1186/s13054-022-04242-3 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM351466630 |
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| 520 | |a © 2023. The Author(s). | ||
| 520 | |a To ensure neuronal survival after severe traumatic brain injury, oxygen supply is essential. Cerebral tissue oxygenation represents the balance between oxygen supply and consumption, largely reflecting the adequacy of cerebral perfusion. Multiple physiological parameters determine the oxygen delivered to the brain, including blood pressure, hemoglobin level, systemic oxygenation, microcirculation and many factors are involved in the delivery of oxygen to its final recipient, through the respiratory chain. Brain tissue hypoxia occurs when the supply of oxygen is not adequate or when for some reasons it cannot be used at the cellular level. The causes of hypoxia are variable and can be analyzed pathophysiologically following "the oxygen route." The current trend is precision medicine, individualized and therapeutically directed to the pathophysiology of specific brain damage; however, this requires the availability of multimodal monitoring. For this purpose, we developed the acronym "THE MANTLE," a bundle of therapeutical interventions, which covers and protects the brain, optimizing the components of the oxygen transport system from ambient air to the mitochondria | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a Brain hypoxia | |
| 650 | 4 | |a Brain oxygenation | |
| 650 | 4 | |a Cerebral ischemia | |
| 650 | 4 | |a Cerebral oxygenation monitoring | |
| 650 | 4 | |a Traumatic brain injury | |
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| 700 | 1 | |a Suarez, Jose Ignacio |e verfasserin |4 aut | |
| 700 | 1 | |a Badenes, Rafael |e verfasserin |4 aut | |
| 700 | 1 | |a Pelosi, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Robba, Chiara |e verfasserin |4 aut | |
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