Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee : Results at three to seven years
Copyright © 2022 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved..
BACKGROUND: Recently, various types of engineered autologous chondrocyte implantation (ACI) have been developed. Atelocollagen-associated ACI (A-ACI) is the only ACI procedure covered by Japanese Health Insurance since 2013. The indications of the A-ACI are traumatic cartilage defects and osteochondral dissecans (OCD) for knee joints.
PURPOSE: To evaluate midterm clinical results after A-ACI for the treatment for full-thickness cartilage defects of the knee.
METHODS: Thirteen consecutive patients who underwent A-ACI between 2014 and 2018 had been prospectively enrolled in this study. There were 11 men and 2 women with a mean age of 34 years at the time of surgery. The causes of the cartilage defect were trauma in 10 knees and OCD in 3 knees. The total number of lesions was 15, which were comprised of the medial femoral condyle in 5 knees, the lateral femoral condyle in 5 knees, and the femoral trochlea in 5 knees. The mean size of the lesion was 5.3 cm2. Each knee was clinically and radiologically evaluated preoperatively and postoperatively.
RESULTS: The mean Lysholm score improved significantly from 74.0 points to 94.0 points (p = 0.008) and each subscale in Knee injury and Osteoarthritis Outcome Score improved significantly (p < 0.001) at the mean final follow-up period of 51 months (range, 36-84 months). The magnetic resonance observation of cartilage repair tissue 2.0 score at the mean follow-up of 38 months was significantly higher than that at 2 months postoperatively (p = 0.014). According to the International Cartilage Repair Society (ICRS) grading scale, 3 knees were graded as normal, 3 knees as nearly normal, and 1 knee as severely abnormal in second-look arthroscopic evaluation at a mean of 22 months (range, 8-41 months) after A-ACI.
CONCLUSION: The present study showed a significant subjective and objective clinical improvement in the A-ACI for large cartilage defects of the knee at a mean follow-up of 51 months (range, 36-84 months).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2024 |
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| Erschienen: |
2024 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:29 |
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| Enthalten in: |
Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association - 29(2024), 1 vom: 01. Jan., Seite 207-216 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kaibara, Takuma [VerfasserIn] |
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| Links: |
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| Themen: |
Atelocollagen |
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| Anmerkungen: |
Date Completed 02.01.2024 Date Revised 02.01.2024 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.jos.2022.12.001 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351398546 |
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| 100 | 1 | |a Kaibara, Takuma |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Atelocollagen-associated autologous chondrocyte implantation for the repair of large cartilage defects of the knee |b Results at three to seven years |
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| 500 | |a Date Completed 02.01.2024 | ||
| 500 | |a Date Revised 02.01.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 The Japanese Orthopaedic Association. Published by Elsevier B.V. All rights reserved. | ||
| 520 | |a BACKGROUND: Recently, various types of engineered autologous chondrocyte implantation (ACI) have been developed. Atelocollagen-associated ACI (A-ACI) is the only ACI procedure covered by Japanese Health Insurance since 2013. The indications of the A-ACI are traumatic cartilage defects and osteochondral dissecans (OCD) for knee joints | ||
| 520 | |a PURPOSE: To evaluate midterm clinical results after A-ACI for the treatment for full-thickness cartilage defects of the knee | ||
| 520 | |a METHODS: Thirteen consecutive patients who underwent A-ACI between 2014 and 2018 had been prospectively enrolled in this study. There were 11 men and 2 women with a mean age of 34 years at the time of surgery. The causes of the cartilage defect were trauma in 10 knees and OCD in 3 knees. The total number of lesions was 15, which were comprised of the medial femoral condyle in 5 knees, the lateral femoral condyle in 5 knees, and the femoral trochlea in 5 knees. The mean size of the lesion was 5.3 cm2. Each knee was clinically and radiologically evaluated preoperatively and postoperatively | ||
| 520 | |a RESULTS: The mean Lysholm score improved significantly from 74.0 points to 94.0 points (p = 0.008) and each subscale in Knee injury and Osteoarthritis Outcome Score improved significantly (p < 0.001) at the mean final follow-up period of 51 months (range, 36-84 months). The magnetic resonance observation of cartilage repair tissue 2.0 score at the mean follow-up of 38 months was significantly higher than that at 2 months postoperatively (p = 0.014). According to the International Cartilage Repair Society (ICRS) grading scale, 3 knees were graded as normal, 3 knees as nearly normal, and 1 knee as severely abnormal in second-look arthroscopic evaluation at a mean of 22 months (range, 8-41 months) after A-ACI | ||
| 520 | |a CONCLUSION: The present study showed a significant subjective and objective clinical improvement in the A-ACI for large cartilage defects of the knee at a mean follow-up of 51 months (range, 36-84 months) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Atelocollagen | |
| 650 | 4 | |a Autologous chondrocyte implantation | |
| 650 | 4 | |a Knee | |
| 650 | 4 | |a Large cartilage defect | |
| 650 | 7 | |a atelocollagen |2 NLM | |
| 700 | 1 | |a Kondo, Eiji |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuoka, Masatake |e verfasserin |4 aut | |
| 700 | 1 | |a Iwasaki, Koji |e verfasserin |4 aut | |
| 700 | 1 | |a Onodera, Tomohiro |e verfasserin |4 aut | |
| 700 | 1 | |a Sakamoto, Keita |e verfasserin |4 aut | |
| 700 | 1 | |a Oda, Yoshitaka |e verfasserin |4 aut | |
| 700 | 1 | |a Tanei, Zen-Ichi |e verfasserin |4 aut | |
| 700 | 1 | |a Momma, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Shinya |e verfasserin |4 aut | |
| 700 | 1 | |a Iwasaki, Norimasa |e verfasserin |4 aut | |
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