Standardized RS Ratio Metrics To Assess Tuberculosis Antimicrobial Efficacy and Potency
The sigmoid Emax model was used to describe the rRNA synthesis ratio (RS ratio) response of Mycobacterium tuberculosis to antimicrobial concentration. RS-Emax measures the maximal ability of a drug to inhibit the RS ratio and can be used to rank-order drugs based on their RS ratio effect. RS-EC90 is the concentration needed to achieve 90% of the RS-Emax, which may guide dose selection to achieve a maximal RS ratio effect in vivo.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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| Enthalten in: |
Antimicrobial agents and chemotherapy - 67(2023), 1 vom: 24. Jan., Seite e0148322 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Reichlen, Matthew J [VerfasserIn] |
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| Links: |
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| Themen: |
Anti-Infective Agents |
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| Anmerkungen: |
Date Completed 26.01.2023 Date Revised 10.07.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1128/aac.01483-22 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351332391 |
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| 520 | |a The sigmoid Emax model was used to describe the rRNA synthesis ratio (RS ratio) response of Mycobacterium tuberculosis to antimicrobial concentration. RS-Emax measures the maximal ability of a drug to inhibit the RS ratio and can be used to rank-order drugs based on their RS ratio effect. RS-EC90 is the concentration needed to achieve 90% of the RS-Emax, which may guide dose selection to achieve a maximal RS ratio effect in vivo | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Mycobacterium tuberculosis | |
| 650 | 4 | |a RS ratio | |
| 650 | 4 | |a antibiotic | |
| 650 | 4 | |a antimicrobial | |
| 650 | 4 | |a drug effects | |
| 650 | 4 | |a drug therapy | |
| 650 | 4 | |a precursor rRNA | |
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| 700 | 1 | |a Born, Sarah E M |e verfasserin |4 aut | |
| 700 | 1 | |a Lyons, Michael A |e verfasserin |4 aut | |
| 700 | 1 | |a Rossmassler, Karen |e verfasserin |4 aut | |
| 700 | 1 | |a Reid, Justin |e verfasserin |4 aut | |
| 700 | 1 | |a Robertson, Gregory T |e verfasserin |4 aut | |
| 700 | 1 | |a Walter, Nicholas D |e verfasserin |4 aut | |
| 700 | 1 | |a Voskuil, Martin I |e verfasserin |4 aut | |
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