Clinical scenarios of hypertrophic cardiomyopathy-related mortality : Relevance of age and stage of disease at presentation
Copyright © 2023 Elsevier B.V. All rights reserved..
The evolving epidemiology of hypertrophic cardiomyopathy (HCM) has progressively changed our perception of HCM-related mortality. However, recent studies detailing individual causes of death based on age and clinical setting are lacking. Thus, the present study aimed to describe the modes of death in a consecutive cohort of HCM patients based on presenting clinical features and stage of disease.
METHODS: By retrospective analysis of a large HCM cohort, we identified 161 patients with >1 year follow-up who died between 2000 and 2020 and thoroughly investigated their modes of death. HCM stage at presentation was defined as "classic", "adverse remodeling" or "overt dysfunction".
RESULTS: Of the 161 patients, 103 (64%) died of HCM-related causes, whereas 58 (36%) died of non-HCM-related causes. Patients who died of HCM-related causes were younger than those who died of non-HCM related causes. The most common cause of death was heart failure (HF). Sudden cardiac death (SCD) ranked third, after non cardiovascular death, and mostly occurred in young individuals. The proportion of HF related death and SCD per stage of disease was 14% and 27% in "classic", 38% and 21% in "adverse remodeling" and 74% and 10% in "overt dysfunction".
CONCLUSIONS: Most HCM patients die due to complications of their own disease, mainly in the context of HF. While SCD tends to be juvenile, HF related deaths often occur in age groups no longer amenable to cardiac transplant. Modes of death vary with the stage of disease, with SCD becoming less prevalent in more advanced phases, when competitive risk of HF becomes overwhelming.
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CommentIn: Int J Cardiol. 2023 Apr 1;376:97-99. - PMID 36758866 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
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Zur Gesamtaufnahme - volume:374 |
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| Enthalten in: |
International journal of cardiology - 374(2023) vom: 01. März, Seite 65-72 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zampieri, Mattia [VerfasserIn] |
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Age |
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| Anmerkungen: |
Date Completed 07.02.2023 Date Revised 27.06.2023 published: Print-Electronic CommentIn: Int J Cardiol. 2023 Apr 1;376:97-99. - PMID 36758866 Citation Status MEDLINE |
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| doi: |
10.1016/j.ijcard.2022.12.056 |
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NLM351326618 |
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| 245 | 1 | 0 | |a Clinical scenarios of hypertrophic cardiomyopathy-related mortality |b Relevance of age and stage of disease at presentation |
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| 500 | |a Date Revised 27.06.2023 | ||
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| 500 | |a CommentIn: Int J Cardiol. 2023 Apr 1;376:97-99. - PMID 36758866 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier B.V. All rights reserved. | ||
| 520 | |a The evolving epidemiology of hypertrophic cardiomyopathy (HCM) has progressively changed our perception of HCM-related mortality. However, recent studies detailing individual causes of death based on age and clinical setting are lacking. Thus, the present study aimed to describe the modes of death in a consecutive cohort of HCM patients based on presenting clinical features and stage of disease | ||
| 520 | |a METHODS: By retrospective analysis of a large HCM cohort, we identified 161 patients with >1 year follow-up who died between 2000 and 2020 and thoroughly investigated their modes of death. HCM stage at presentation was defined as "classic", "adverse remodeling" or "overt dysfunction" | ||
| 520 | |a RESULTS: Of the 161 patients, 103 (64%) died of HCM-related causes, whereas 58 (36%) died of non-HCM-related causes. Patients who died of HCM-related causes were younger than those who died of non-HCM related causes. The most common cause of death was heart failure (HF). Sudden cardiac death (SCD) ranked third, after non cardiovascular death, and mostly occurred in young individuals. The proportion of HF related death and SCD per stage of disease was 14% and 27% in "classic", 38% and 21% in "adverse remodeling" and 74% and 10% in "overt dysfunction" | ||
| 520 | |a CONCLUSIONS: Most HCM patients die due to complications of their own disease, mainly in the context of HF. While SCD tends to be juvenile, HF related deaths often occur in age groups no longer amenable to cardiac transplant. Modes of death vary with the stage of disease, with SCD becoming less prevalent in more advanced phases, when competitive risk of HF becomes overwhelming | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Age | |
| 650 | 4 | |a Heart failure | |
| 650 | 4 | |a Hypertrophic cardiomyopathy | |
| 650 | 4 | |a Mortality | |
| 650 | 4 | |a Stage | |
| 650 | 4 | |a Sudden cardiac death | |
| 700 | 1 | |a Salvi, Samuele |e verfasserin |4 aut | |
| 700 | 1 | |a Fumagalli, Carlo |e verfasserin |4 aut | |
| 700 | 1 | |a Argirò, Alessia |e verfasserin |4 aut | |
| 700 | 1 | |a Zocchi, Chiara |e verfasserin |4 aut | |
| 700 | 1 | |a Del Franco, Annamaria |e verfasserin |4 aut | |
| 700 | 1 | |a Iannaccone, Giulia |e verfasserin |4 aut | |
| 700 | 1 | |a Giovani, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Ferrantini, Cecilia |e verfasserin |4 aut | |
| 700 | 1 | |a Palinkas, Eszter Dalma |e verfasserin |4 aut | |
| 700 | 1 | |a Cappelli, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Olivotto, Iacopo |e verfasserin |4 aut | |
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