Additive manufacturing of PLA-Mg composite scaffolds for hard tissue engineering applications
Copyright © 2023 Elsevier Ltd. All rights reserved..
Polylactic acid (PLA) is considered as a great option to be employed as 3D porous scaffold in hard tissue engineering applications owing to its excellent biocompatibility and processability. However, relatively weak mechanical properties and inappropriate biodegradability limit its extensive usage. In order to overcome the mentioned challenges, micrometric magnesium particles were incorporated into the PLA matrix by the fused deposition modeling (FDM) technique. The effects of various Mg contents (i.e., 2, 4, 6, 8 and 10 wt%) on the structural, thermal, rheological, mechanical, wettability, degradability characteristics and cellular behavior of the 3D porous PLA-Mg composite scaffolds were examined. The developed PLA-Mg composites exhibit an interconnected porous structure with a mostly uniform distribution of Mg particles in the PLA matrix. It was found that incorporation of Mg particles into the PLA matrix enhances the mechanical, physical, chemical and biological characteristics of PLA. The cell studies demonstrate that the PLA-6Mg composite scaffold provides the best cellular response in terms of cell atachment and viability. The obtained results in this investigation greatly suggest that the 3D-printed PLA-Mg composite scaffold is a promising candidate for hard tissue engineering applications.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:138 |
|---|---|
| Enthalten in: |
Journal of the mechanical behavior of biomedical materials - 138(2023) vom: 15. Feb., Seite 105655 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Bakhshi, Rasoul [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
3D printing |
|---|
| Anmerkungen: |
Date Completed 18.01.2023 Date Revised 23.02.2023 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1016/j.jmbbm.2023.105655 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM351321705 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM351321705 | ||
| 003 | DE-627 | ||
| 005 | 20231226051102.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.jmbbm.2023.105655 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1171.xml |
| 035 | |a (DE-627)NLM351321705 | ||
| 035 | |a (NLM)36621086 | ||
| 035 | |a (PII)S1751-6161(23)00008-5 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bakhshi, Rasoul |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Additive manufacturing of PLA-Mg composite scaffolds for hard tissue engineering applications |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 18.01.2023 | ||
| 500 | |a Date Revised 23.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2023 Elsevier Ltd. All rights reserved. | ||
| 520 | |a Polylactic acid (PLA) is considered as a great option to be employed as 3D porous scaffold in hard tissue engineering applications owing to its excellent biocompatibility and processability. However, relatively weak mechanical properties and inappropriate biodegradability limit its extensive usage. In order to overcome the mentioned challenges, micrometric magnesium particles were incorporated into the PLA matrix by the fused deposition modeling (FDM) technique. The effects of various Mg contents (i.e., 2, 4, 6, 8 and 10 wt%) on the structural, thermal, rheological, mechanical, wettability, degradability characteristics and cellular behavior of the 3D porous PLA-Mg composite scaffolds were examined. The developed PLA-Mg composites exhibit an interconnected porous structure with a mostly uniform distribution of Mg particles in the PLA matrix. It was found that incorporation of Mg particles into the PLA matrix enhances the mechanical, physical, chemical and biological characteristics of PLA. The cell studies demonstrate that the PLA-6Mg composite scaffold provides the best cellular response in terms of cell atachment and viability. The obtained results in this investigation greatly suggest that the 3D-printed PLA-Mg composite scaffold is a promising candidate for hard tissue engineering applications | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a 3D printing | |
| 650 | 4 | |a FDM | |
| 650 | 4 | |a Hard tissue scaffold | |
| 650 | 4 | |a Interconnected porous structure | |
| 650 | 4 | |a PLA-Mg composite | |
| 650 | 7 | |a poly(lactide) |2 NLM | |
| 650 | 7 | |a 459TN2L5F5 |2 NLM | |
| 650 | 7 | |a Polyesters |2 NLM | |
| 700 | 1 | |a Mohammadi-Zerankeshi, Meysam |e verfasserin |4 aut | |
| 700 | 1 | |a Mehrabi-Dehdezi, Melika |e verfasserin |4 aut | |
| 700 | 1 | |a Alizadeh, Reza |e verfasserin |4 aut | |
| 700 | 1 | |a Labbaf, Sheyda |e verfasserin |4 aut | |
| 700 | 1 | |a Abachi, Parvin |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of the mechanical behavior of biomedical materials |d 2008 |g 138(2023) vom: 15. Feb., Seite 105655 |w (DE-627)NLM179225219 |x 1878-0180 |7 nnns |
| 773 | 1 | 8 | |g volume:138 |g year:2023 |g day:15 |g month:02 |g pages:105655 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.jmbbm.2023.105655 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 138 |j 2023 |b 15 |c 02 |h 105655 | ||