Theranostic doxorubicin encapsulated FeAu alloymetal-organic framework nanostructures enable magnetic hyperthermia and medical imaging in oral carcinoma

Copyright © 2023. Published by Elsevier Inc..

Metal-organic frameworks (MOFs) have emerged as attractive candidates in cancer theranostics due to their ability to envelop magnetic nanoparticles, resulting in reduced cytotoxicity and high porosity, enabling chemodrug encapsulation. Here, FeAu alloy nanoparticles (FeAu NPs) are synthesized and coated with MIL-100(Fe) MOFs to fabricate FeAu@MOF nanostructures. We encapsulated Doxorubicin within the nanostructures and evaluated the suitability of this platform for medical imaging and cancer theranostics. FeAu@MOF nanostructures (FeAu@MIL-100(Fe)) exhibited superparamagnetism, magnetic hyperthermia behavior and displayed DOX encapsulation and release efficiency of 69.95 % and 97.19 %, respectively, when stimulated with alternating magnetic field (AMF). In-vitro experiments showed that AMF-induced hyperthermia resulted in 90 % HSC-3 oral squamous carcinoma cell death, indicating application in cancer theranostics. Finally, in an in-vivo mouse model, FeAu@MOF nanostructures improved image contrast, reduced tumor volume by 30-fold and tumor weight by 10-fold, which translated to enhancement in cumulative survival, highlighting the prospect of this platform for oral cancer treatment.

Media Type:

Electronic Article

Year of Publication:

2023

Publication:

2023

Contained In:

To Main Record - volume:48

Contained In:

Nanomedicine : nanotechnology, biology, and medicine - 48(2023) vom: 01. Feb., Seite 102652

Language:

English

Contributors:

Dhawan, Udesh [Author]
Tseng, Ching-Li [Author]
Wu, Ping-Hsuan [Author]
Liao, Mei-Yi [Author]
Wang, Huey-Yuan [Author]
Wu, Kevin C-W [Author]
Chung, Ren-Jei [Author]

Links:

Volltext

Keywords:

80168379AG
Cancer theranostics
Doxorubicin
Hyperthermia
Iron‑gold alloy nanoparticles
Journal Article
Metal-Organic Frameworks
Metal-organic framework
Oral squamous carcinoma

Notes:

Date Completed 14.02.2023

Date Revised 14.02.2023

published: Print-Electronic

Citation Status MEDLINE

doi:

10.1016/j.nano.2023.102652

funding:

Supporting institution / Project title:

PPN (Catalogue-ID):

NLM351311920