Two new chemical constituents from the stem and branch of Tripterygium wilfordii
A chemical investigation of 95% ethanol extract from the stem and branch of Tripterygium wilfordii has resulted in the isolation and characterization of two new compounds, one neolignan (1) and one phenylalanine derivative (2), as well as four known compounds (3-6). The structures of the new compounds were determined based on extensive spectroscopic analyses. The absolute configuration of compound 1 was defined by X-ray crystallographic analyses and electronic circular dichroism calculation. In addition, compounds 2 and 4-6 exhibited inhibitory effects against NO production in LPS-induced RAW 264.7 macrophages with the IC50 value ranging from 3.51 μM to 30.40 μM.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:25 |
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| Enthalten in: |
Journal of Asian natural products research - 25(2023), 9 vom: 27. Sept., Seite 834-841 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Hu, Ya-Lin [VerfasserIn] |
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| Links: |
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| Themen: |
31C4KY9ESH |
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| Anmerkungen: |
Date Completed 28.08.2023 Date Revised 28.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/10286020.2022.2164490 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351289585 |
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| 500 | |a Date Revised 28.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a A chemical investigation of 95% ethanol extract from the stem and branch of Tripterygium wilfordii has resulted in the isolation and characterization of two new compounds, one neolignan (1) and one phenylalanine derivative (2), as well as four known compounds (3-6). The structures of the new compounds were determined based on extensive spectroscopic analyses. The absolute configuration of compound 1 was defined by X-ray crystallographic analyses and electronic circular dichroism calculation. In addition, compounds 2 and 4-6 exhibited inhibitory effects against NO production in LPS-induced RAW 264.7 macrophages with the IC50 value ranging from 3.51 μM to 30.40 μM | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Celastraceae; Tripterygium wilfordii | |
| 650 | 4 | |a ECD | |
| 650 | 4 | |a anti-inflammatory activity | |
| 650 | 4 | |a neolignan | |
| 650 | 4 | |a phenylalanine derivative | |
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| 650 | 7 | |a 31C4KY9ESH |2 NLM | |
| 700 | 1 | |a Hu, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Tian-Qi |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Hong-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Huai-Yu |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xia |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Fan, Chun-Lin |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Guang-Xiong |e verfasserin |4 aut | |
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