Cardiometabolic health improvements upon dietary intervention are driven by tissue-specific insulin resistance phenotype : A precision nutrition trial
Copyright © 2022 The Author(s). Published by Elsevier Inc. All rights reserved..
Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25-40 kg/m2, 40-75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. Clinicaltrials.gov registration: NCT03708419, CCMO registration NL63768.068.17.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2023 |
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Erschienen: |
2023 |
Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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Enthalten in: |
Cell metabolism - 35(2023), 1 vom: 03. Jan., Seite 71-83.e5 |
Sprache: |
Englisch |
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Beteiligte Personen: |
Trouwborst, Inez [VerfasserIn] |
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Links: |
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Anmerkungen: |
Date Completed 13.01.2023 Date Revised 13.02.2023 published: Print ClinicalTrials.gov: NCT03708419 Citation Status MEDLINE |
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doi: |
10.1016/j.cmet.2022.12.002 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM35110495X |
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520 | |a Precision nutrition based on metabolic phenotype may increase the effectiveness of interventions. In this proof-of-concept study, we investigated the effect of modulating dietary macronutrient composition according to muscle insulin-resistant (MIR) or liver insulin-resistant (LIR) phenotypes on cardiometabolic health. Women and men with MIR or LIR (n = 242, body mass index [BMI] 25-40 kg/m2, 40-75 years) were randomized to phenotype diet (PhenoDiet) group A or B and followed a 12-week high-monounsaturated fatty acid (HMUFA) diet or low-fat, high-protein, and high-fiber diet (LFHP) (PhenoDiet group A, MIR/HMUFA and LIR/LFHP; PhenoDiet group B, MIR/LFHP and LIR/HMUFA). PhenoDiet group B showed no significant improvements in the primary outcome disposition index, but greater improvements in insulin sensitivity, glucose homeostasis, serum triacylglycerol, and C-reactive protein compared with PhenoDiet group A were observed. We demonstrate that modulating macronutrient composition within the dietary guidelines based on tissue-specific insulin resistance (IR) phenotype enhances cardiometabolic health improvements. Clinicaltrials.gov registration: NCT03708419, CCMO registration NL63768.068.17 | ||
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700 | 1 | |a Hul, Gabby B |e verfasserin |4 aut | |
700 | 1 | |a Wanders, Lisa |e verfasserin |4 aut | |
700 | 1 | |a Erdos, Balázs |e verfasserin |4 aut | |
700 | 1 | |a Péter, Szabolcs |e verfasserin |4 aut | |
700 | 1 | |a Singh-Povel, Cécile M |e verfasserin |4 aut | |
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700 | 1 | |a Afman, Lydia A |e verfasserin |4 aut | |
700 | 1 | |a Blaak, Ellen E |e verfasserin |4 aut | |
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