Mediterranean diet related metabolite profiles and cognitive performance
Copyright © 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved..
BACKGROUND & AIMS: Evidence suggests that adherence to the Mediterranean diet (MedDiet) affects human metabolism and may contribute to better cognitive performance. However, the underlying mechanisms are not clear.
OBJECTIVE: We generated a metabolite profile for adherence to MedDiet and evaluated its cross-sectional association with aspects of cognitive performance.
METHODS: A total of 1250 healthy Greek middle-aged adults from the Epirus Health Study cohort were included in the analysis. Adherence to the MedDiet was assessed using the 14-point Mediterranean Diet Adherence Screener (MEDAS); cognition was measured using the Trail Making Test, the Verbal Fluency test and the Logical Memory test. A targeted metabolite profiling (n = 250 metabolites) approach was applied, using a high-throughput nuclear magnetic resonance platform. We used elastic net regularized regressions, with a 10-fold cross-validation procedure, to identify a metabolite profile for MEDAS. We evaluated the associations of the identified metabolite profile and MEDAS with cognitive tests, using multivariable linear regression models.
RESULTS: We identified a metabolite profile composed of 42 metabolites, mainly lipoprotein subclasses and fatty acids, significantly correlated with MedDiet adherence (Pearson r = 0.35, P-value = 5.5 × 10-37). After adjusting for known risk factors and accounting for multiple testing, the metabolite profile and MEDAS were not associated with the cognitive tests.
CONCLUSIONS: A plasma metabolite profile related to better adherence to the MedDiet was not associated with the tested aspects of cognitive performance, in a middle-aged Mediterranean population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
Clinical nutrition (Edinburgh, Scotland) - 42(2023), 2 vom: 15. Feb., Seite 173-181 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Papandreou, Christopher [VerfasserIn] |
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| Links: |
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| Themen: |
Cognition |
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| Anmerkungen: |
Date Completed 02.02.2023 Date Revised 26.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clnu.2022.12.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Mediterranean diet related metabolite profiles and cognitive performance |
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| 500 | |a Date Revised 26.02.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2022 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved. | ||
| 520 | |a BACKGROUND & AIMS: Evidence suggests that adherence to the Mediterranean diet (MedDiet) affects human metabolism and may contribute to better cognitive performance. However, the underlying mechanisms are not clear | ||
| 520 | |a OBJECTIVE: We generated a metabolite profile for adherence to MedDiet and evaluated its cross-sectional association with aspects of cognitive performance | ||
| 520 | |a METHODS: A total of 1250 healthy Greek middle-aged adults from the Epirus Health Study cohort were included in the analysis. Adherence to the MedDiet was assessed using the 14-point Mediterranean Diet Adherence Screener (MEDAS); cognition was measured using the Trail Making Test, the Verbal Fluency test and the Logical Memory test. A targeted metabolite profiling (n = 250 metabolites) approach was applied, using a high-throughput nuclear magnetic resonance platform. We used elastic net regularized regressions, with a 10-fold cross-validation procedure, to identify a metabolite profile for MEDAS. We evaluated the associations of the identified metabolite profile and MEDAS with cognitive tests, using multivariable linear regression models | ||
| 520 | |a RESULTS: We identified a metabolite profile composed of 42 metabolites, mainly lipoprotein subclasses and fatty acids, significantly correlated with MedDiet adherence (Pearson r = 0.35, P-value = 5.5 × 10-37). After adjusting for known risk factors and accounting for multiple testing, the metabolite profile and MEDAS were not associated with the cognitive tests | ||
| 520 | |a CONCLUSIONS: A plasma metabolite profile related to better adherence to the MedDiet was not associated with the tested aspects of cognitive performance, in a middle-aged Mediterranean population | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Cognition | |
| 650 | 4 | |a Executive function | |
| 650 | 4 | |a Mediterranean diet | |
| 650 | 4 | |a Memory | |
| 650 | 4 | |a Metabolomics | |
| 700 | 1 | |a Papagiannopoulos, Christos |e verfasserin |4 aut | |
| 700 | 1 | |a Koutsonida, Myrto |e verfasserin |4 aut | |
| 700 | 1 | |a Kanellopoulou, Afroditi |e verfasserin |4 aut | |
| 700 | 1 | |a Markozannes, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Polychronidis, Georgios |e verfasserin |4 aut | |
| 700 | 1 | |a Tzakos, Andreas G |e verfasserin |4 aut | |
| 700 | 1 | |a Fragkiadakis, Georgios A |e verfasserin |4 aut | |
| 700 | 1 | |a Evangelou, Evangelos |e verfasserin |4 aut | |
| 700 | 1 | |a Ntzani, Evangelia |e verfasserin |4 aut | |
| 700 | 1 | |a Tzoulaki, Ioanna |e verfasserin |4 aut | |
| 700 | 1 | |a Aretouli, Eleni |e verfasserin |4 aut | |
| 700 | 1 | |a Tsilidis, Konstantinos K |e verfasserin |4 aut | |
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