The effects of recruitment of renal functional reserve on renal cortical and medullary oxygenation in non-anesthetized sheep
© 2023 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society..
AIM: Recruitment of renal functional reserve (RFR) with amino acid loading increases renal blood flow and glomerular filtration rate. However, its effects on renal cortical and medullary oxygenation have not been determined. Accordingly, we tested the effects of recruitment of RFR on renal cortical and medullary oxygenation in non-anesthetized sheep.
METHODS: Under general anesthesia, we instrumented 10 sheep to enable subsequent continuous measurements of systemic and renal hemodynamics, renal oxygen delivery and consumption, and cortical and medullary tissue oxygen tension (PO2 ). We then measured the effects of recruitment of RFR with an intravenous infusion of 500 ml of a clinically used amino acid solution (10% Synthamin® 17) in the non-anesthetized state.
RESULTS: Compared with baseline, Synthamin® 17 infusion significantly increased renal oxygen delivery mean ± SD maximum increase: (from 0.79 ± 0.17 to 1.06 ± 0.16 ml/kg/min, p < 0.001), renal oxygen consumption (from 0.08 ± 0.01 to 0.15 ± 0.02 ml/kg/min, p < 0.001), and glomerular filtration rate (+45.2 ± 2.7%, p < 0.001). Renal cortical tissue PO2 increased by a maximum of 26.4 ± 1.1% (p = 0.001) and medullary tissue PO2 increased by a maximum of 23.9 ± 2.8% (p = 0. 001).
CONCLUSIONS: In non-anesthetized healthy sheep, recruitment of RFR improved renal cortical and medullary oxygenation. These observations might have implications for the use of recruitment of RFR for diagnostic and therapeutic purposes.
| Errataetall: |
CommentIn: Acta Physiol (Oxf). 2023 Apr;237(4):e13941. - PMID 36705598 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:237 |
|---|---|
| Enthalten in: |
Acta physiologica (Oxford, England) - 237(2023), 4 vom: 11. Apr., Seite e13919 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Jufar, Alemayehu H [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Amino acid infusion |
|---|
| Anmerkungen: |
Date Completed 27.03.2023 Date Revised 05.03.2024 published: Print-Electronic CommentIn: Acta Physiol (Oxf). 2023 Apr;237(4):e13941. - PMID 36705598 Citation Status MEDLINE |
|---|
| doi: |
10.1111/apha.13919 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM35109539X |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM35109539X | ||
| 003 | DE-627 | ||
| 005 | 20240305231847.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1111/apha.13919 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1317.xml |
| 035 | |a (DE-627)NLM35109539X | ||
| 035 | |a (NLM)36598336 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Jufar, Alemayehu H |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The effects of recruitment of renal functional reserve on renal cortical and medullary oxygenation in non-anesthetized sheep |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 27.03.2023 | ||
| 500 | |a Date Revised 05.03.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Acta Physiol (Oxf). 2023 Apr;237(4):e13941. - PMID 36705598 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2023 The Authors. Acta Physiologica published by John Wiley & Sons Ltd on behalf of Scandinavian Physiological Society. | ||
| 520 | |a AIM: Recruitment of renal functional reserve (RFR) with amino acid loading increases renal blood flow and glomerular filtration rate. However, its effects on renal cortical and medullary oxygenation have not been determined. Accordingly, we tested the effects of recruitment of RFR on renal cortical and medullary oxygenation in non-anesthetized sheep | ||
| 520 | |a METHODS: Under general anesthesia, we instrumented 10 sheep to enable subsequent continuous measurements of systemic and renal hemodynamics, renal oxygen delivery and consumption, and cortical and medullary tissue oxygen tension (PO2 ). We then measured the effects of recruitment of RFR with an intravenous infusion of 500 ml of a clinically used amino acid solution (10% Synthamin® 17) in the non-anesthetized state | ||
| 520 | |a RESULTS: Compared with baseline, Synthamin® 17 infusion significantly increased renal oxygen delivery mean ± SD maximum increase: (from 0.79 ± 0.17 to 1.06 ± 0.16 ml/kg/min, p < 0.001), renal oxygen consumption (from 0.08 ± 0.01 to 0.15 ± 0.02 ml/kg/min, p < 0.001), and glomerular filtration rate (+45.2 ± 2.7%, p < 0.001). Renal cortical tissue PO2 increased by a maximum of 26.4 ± 1.1% (p = 0.001) and medullary tissue PO2 increased by a maximum of 23.9 ± 2.8% (p = 0. 001) | ||
| 520 | |a CONCLUSIONS: In non-anesthetized healthy sheep, recruitment of RFR improved renal cortical and medullary oxygenation. These observations might have implications for the use of recruitment of RFR for diagnostic and therapeutic purposes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a amino acid infusion | |
| 650 | 4 | |a glomerular filtration rate | |
| 650 | 4 | |a renal functional reserve | |
| 650 | 4 | |a renal oxygenation | |
| 650 | 4 | |a renal perfusion | |
| 650 | 7 | |a Oxygen |2 NLM | |
| 650 | 7 | |a S88TT14065 |2 NLM | |
| 700 | 1 | |a Evans, Roger G |e verfasserin |4 aut | |
| 700 | 1 | |a May, Clive N |e verfasserin |4 aut | |
| 700 | 1 | |a Hood, Sally G |e verfasserin |4 aut | |
| 700 | 1 | |a Betrie, Ashenafi H |e verfasserin |4 aut | |
| 700 | 1 | |a Trask-Marino, Anton |e verfasserin |4 aut | |
| 700 | 1 | |a Bellomo, Rinaldo |e verfasserin |4 aut | |
| 700 | 1 | |a Lankadeva, Yugeesh R |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Acta physiologica (Oxford, England) |d 2006 |g 237(2023), 4 vom: 11. Apr., Seite e13919 |w (DE-627)NLM160895634 |x 1748-1716 |7 nnns |
| 773 | 1 | 8 | |g volume:237 |g year:2023 |g number:4 |g day:11 |g month:04 |g pages:e13919 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1111/apha.13919 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 237 |j 2023 |e 4 |b 11 |c 04 |h e13919 | ||