COVID-19 international experience in paediatric patients with congenital heart disease
© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVE: As COVID-19 continues to affect the global population, it is crucial to study the impact of the disease in vulnerable populations. This study of a diverse, international cohort aims to provide timely, experiential data on the course of disease in paediatric patients with congenital heart disease (CHD).
METHODS: Data were collected by capitalising on two pre-existing CHD registries, the International Quality Improvement Collaborative for Congenital Heart Disease: Improving Care in Low- and Middle-Income Countries and the Congenital Cardiac Catheterization Project on Outcomes. 35 participating sites reported data for all patients under 18 years of age with diagnosed CHD and known COVID-19 illness during 2020 identified at their institution. Patients were classified as low, moderate or high risk for moderate or severe COVID-19 illness based on patient anatomy, physiology and genetic syndrome using current published guidelines. Association of risk factors with hospitalisation and intensive care unit (ICU) level care were assessed.
RESULTS: The study included 339 COVID-19 cases in paediatric patients with CHD from 35 sites worldwide. Of these cases, 84 patients (25%) required hospitalisation, and 40 (12%) required ICU care. Age <1 year, recent cardiac intervention, anatomical complexity, clinical cardiac status and overall risk were all significantly associated with need for hospitalisation and ICU admission. A multivariable model for ICU admission including clinical cardiac status and recent cardiac intervention produced a c-statistic of 0.86.
CONCLUSIONS: These observational data suggest risk factors for hospitalisation related to COVID-19 in paediatric CHD include age, lower functional cardiac status and recent cardiac interventions. There is a need for further data to identify factors relevant to the care of patients with CHD who contract COVID-19 illness.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:109 |
|---|---|
| Enthalten in: |
Heart (British Cardiac Society) - 109(2023), 9 vom: 12. Apr., Seite 710-718 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Yeh, Mary J [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COVID-19 |
|---|
| Anmerkungen: |
Date Completed 14.04.2023 Date Revised 28.04.2023 published: Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1136/heartjnl-2022-321208 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM351092730 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM351092730 | ||
| 003 | DE-627 | ||
| 005 | 20231226050517.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/heartjnl-2022-321208 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1170.xml |
| 035 | |a (DE-627)NLM351092730 | ||
| 035 | |a (NLM)36598072 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Yeh, Mary J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a COVID-19 international experience in paediatric patients with congenital heart disease |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 14.04.2023 | ||
| 500 | |a Date Revised 28.04.2023 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVE: As COVID-19 continues to affect the global population, it is crucial to study the impact of the disease in vulnerable populations. This study of a diverse, international cohort aims to provide timely, experiential data on the course of disease in paediatric patients with congenital heart disease (CHD) | ||
| 520 | |a METHODS: Data were collected by capitalising on two pre-existing CHD registries, the International Quality Improvement Collaborative for Congenital Heart Disease: Improving Care in Low- and Middle-Income Countries and the Congenital Cardiac Catheterization Project on Outcomes. 35 participating sites reported data for all patients under 18 years of age with diagnosed CHD and known COVID-19 illness during 2020 identified at their institution. Patients were classified as low, moderate or high risk for moderate or severe COVID-19 illness based on patient anatomy, physiology and genetic syndrome using current published guidelines. Association of risk factors with hospitalisation and intensive care unit (ICU) level care were assessed | ||
| 520 | |a RESULTS: The study included 339 COVID-19 cases in paediatric patients with CHD from 35 sites worldwide. Of these cases, 84 patients (25%) required hospitalisation, and 40 (12%) required ICU care. Age <1 year, recent cardiac intervention, anatomical complexity, clinical cardiac status and overall risk were all significantly associated with need for hospitalisation and ICU admission. A multivariable model for ICU admission including clinical cardiac status and recent cardiac intervention produced a c-statistic of 0.86 | ||
| 520 | |a CONCLUSIONS: These observational data suggest risk factors for hospitalisation related to COVID-19 in paediatric CHD include age, lower functional cardiac status and recent cardiac interventions. There is a need for further data to identify factors relevant to the care of patients with CHD who contract COVID-19 illness | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Global Health | |
| 650 | 4 | |a Heart Defects, Congenital | |
| 650 | 4 | |a Risk Factors | |
| 700 | 1 | |a Bergersen, Lisa |e verfasserin |4 aut | |
| 700 | 1 | |a Gauvreau, Kimberlee |e verfasserin |4 aut | |
| 700 | 1 | |a Barry, Oliver M |e verfasserin |4 aut | |
| 700 | 1 | |a Batlivala, Sarosh P |e verfasserin |4 aut | |
| 700 | 1 | |a Bjornlund, Elsa |e verfasserin |4 aut | |
| 700 | 1 | |a Boe, Brian |e verfasserin |4 aut | |
| 700 | 1 | |a Caneo, Luiz Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Croti, Ulisses A |e verfasserin |4 aut | |
| 700 | 1 | |a Doyle, Thomas |e verfasserin |4 aut | |
| 700 | 1 | |a Furnaz, Shumaila |e verfasserin |4 aut | |
| 700 | 1 | |a Moraes, Rodrigo Cesar |e verfasserin |4 aut | |
| 700 | 1 | |a O'Byrne, Michael L |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira Paes, Erica |e verfasserin |4 aut | |
| 700 | 1 | |a Palacios-Macedo, Alexis |e verfasserin |4 aut | |
| 700 | 1 | |a Pechilkov, Dimitar |e verfasserin |4 aut | |
| 700 | 1 | |a Sandoval, Nestor Fernando |e verfasserin |4 aut | |
| 700 | 1 | |a Sen, Supratim |e verfasserin |4 aut | |
| 700 | 1 | |a Stajevic, Mila |e verfasserin |4 aut | |
| 700 | 1 | |a Travessa, Marco Antonio Ferreira |e verfasserin |4 aut | |
| 700 | 1 | |a Jenkins, Kathy J |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Heart (British Cardiac Society) |d 1996 |g 109(2023), 9 vom: 12. Apr., Seite 710-718 |w (DE-627)NLM085989274 |x 1468-201X |7 nnns |
| 773 | 1 | 8 | |g volume:109 |g year:2023 |g number:9 |g day:12 |g month:04 |g pages:710-718 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1136/heartjnl-2022-321208 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 109 |j 2023 |e 9 |b 12 |c 04 |h 710-718 | ||