Amitriptyline intoxication in bullfrogs causes widening of QRS complexes in electrocardiogram
Amitriptyline intoxication is caused by its suicidal or accidental overdose. In the present study, by intravenously injecting 1.5 or 3.0 mg/kg amitriptyline into bullfrogs, we actually revealed that amitriptyline causes the widening of QRS complexes in electrocardiogram (ECG). In simultaneous recordings of the cardiac action potential, amitriptyline decreased the slope of phase 0 in the action potential, indicating the inhibition of the inward sodium currents during this phase. The following treatment with sodium bicarbonate quickly restored the widened QRS complexes in the ECG, demonstrating the counteraction with the sodium channel blockade caused by amitriptyline. The dual recordings of ECG waveforms and the action potential in cardiomyocytes enabled us to demonstrate the mechanisms of characteristic ECG abnormalities caused by amitriptyline intoxication.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:85 |
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| Enthalten in: |
The Journal of veterinary medical science - 85(2023), 2 vom: 01. Feb., Seite 175-179 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nagano, Amu [VerfasserIn] |
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| Links: |
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| Themen: |
1806D8D52K |
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| Anmerkungen: |
Date Completed 03.02.2023 Date Revised 18.03.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1292/jvms.22-0494 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM351077723 |
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| 520 | |a Amitriptyline intoxication is caused by its suicidal or accidental overdose. In the present study, by intravenously injecting 1.5 or 3.0 mg/kg amitriptyline into bullfrogs, we actually revealed that amitriptyline causes the widening of QRS complexes in electrocardiogram (ECG). In simultaneous recordings of the cardiac action potential, amitriptyline decreased the slope of phase 0 in the action potential, indicating the inhibition of the inward sodium currents during this phase. The following treatment with sodium bicarbonate quickly restored the widened QRS complexes in the ECG, demonstrating the counteraction with the sodium channel blockade caused by amitriptyline. The dual recordings of ECG waveforms and the action potential in cardiomyocytes enabled us to demonstrate the mechanisms of characteristic ECG abnormalities caused by amitriptyline intoxication | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a amitriptyline | |
| 650 | 4 | |a bullfrog heart | |
| 650 | 4 | |a cardiac action potential | |
| 650 | 4 | |a electrocardiogram (ECG) | |
| 650 | 4 | |a widening of QRS complexes | |
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| 700 | 1 | |a Muto, Mizuki |e verfasserin |4 aut | |
| 700 | 1 | |a Shida, Junko |e verfasserin |4 aut | |
| 700 | 1 | |a Kazama, Itsuro |e verfasserin |4 aut | |
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