1,3,4-Thiadiazole : A Versatile Pharmacophore of Medicinal Significance
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
The 1,3,4-thiadiazole nucleus has attracted the attention of medicinal chemists during the last decades due to its multiple pharmacological activities, such as antiviral, anticancer, antibacterial, and anticonvulsant activity. This scaffold's structural alteration could aid in developing novel therapeutically effective drugs. Incorporating this adaptable pharmacophore into a well-established medicinally active molecule results in hybrid molecules with diverse pharmacological effects. These encouraging reports suggested that this privileged skeleton should be thoroughly researched for medicinal purposes. Hence, an attempt has been made in this compilation to review the structure-activity relationships of numerous thiadiazole derivatives reported in the literature with varied pharmacological properties. This review provides an up-to-date explanation of the various synthesized 1,3,4- thiadiazole analogs and their pharmacological importance.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:19 |
|---|---|
| Enthalten in: |
Medicinal chemistry (Shariqah (United Arab Emirates)) - 19(2023), 8 vom: 02., Seite 730-756 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Bala, Madhu [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
1 |
|---|
| Anmerkungen: |
Date Completed 29.05.2023 Date Revised 29.05.2023 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.2174/1573406419666230102104648 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM351050051 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM351050051 | ||
| 003 | DE-627 | ||
| 005 | 20231226050411.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.2174/1573406419666230102104648 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1170.xml |
| 035 | |a (DE-627)NLM351050051 | ||
| 035 | |a (NLM)36593699 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Bala, Madhu |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a 1,3,4-Thiadiazole |b A Versatile Pharmacophore of Medicinal Significance |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.05.2023 | ||
| 500 | |a Date Revised 29.05.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a The 1,3,4-thiadiazole nucleus has attracted the attention of medicinal chemists during the last decades due to its multiple pharmacological activities, such as antiviral, anticancer, antibacterial, and anticonvulsant activity. This scaffold's structural alteration could aid in developing novel therapeutically effective drugs. Incorporating this adaptable pharmacophore into a well-established medicinally active molecule results in hybrid molecules with diverse pharmacological effects. These encouraging reports suggested that this privileged skeleton should be thoroughly researched for medicinal purposes. Hence, an attempt has been made in this compilation to review the structure-activity relationships of numerous thiadiazole derivatives reported in the literature with varied pharmacological properties. This review provides an up-to-date explanation of the various synthesized 1,3,4- thiadiazole analogs and their pharmacological importance | ||
| 650 | 4 | |a Review | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 1 | |
| 650 | 4 | |a 3 | |
| 650 | 4 | |a 4-Thiadiazole | |
| 650 | 4 | |a antibacterial | |
| 650 | 4 | |a anticancer | |
| 650 | 4 | |a anticholinergic | |
| 650 | 4 | |a antiviral | |
| 650 | 4 | |a clinical indications | |
| 650 | 4 | |a pharmacological activities | |
| 650 | 7 | |a 1,3,4-thiadiazole |2 NLM | |
| 650 | 7 | |a 14IAC3GH7G |2 NLM | |
| 650 | 7 | |a Thiadiazoles |2 NLM | |
| 650 | 7 | |a Anti-Bacterial Agents |2 NLM | |
| 700 | 1 | |a Piplani, Poonam |e verfasserin |4 aut | |
| 700 | 1 | |a Ankalgi, Amardeep |e verfasserin |4 aut | |
| 700 | 1 | |a Jain, Ankit |e verfasserin |4 aut | |
| 700 | 1 | |a Chandel, Lalit |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medicinal chemistry (Shariqah (United Arab Emirates)) |d 2005 |g 19(2023), 8 vom: 02., Seite 730-756 |w (DE-627)NLM163628467 |x 1875-6638 |7 nnns |
| 773 | 1 | 8 | |g volume:19 |g year:2023 |g number:8 |g day:02 |g pages:730-756 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.2174/1573406419666230102104648 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 19 |j 2023 |e 8 |b 02 |h 730-756 | ||