Multishot Diffusion-Weighted MRI of the Breasts in the Supine vs. Prone Position
© 2022 International Society for Magnetic Resonance in Medicine..
BACKGROUND: Diffusion-weighted imaging (DWI) may allow for breast cancer screening MRI without a contrast injection. Multishot methods improve prone DWI of the breasts but face different challenges in the supine position.
PURPOSE: To establish a multishot DWI (msDWI) protocol for supine breast MRI and to evaluate the performance of supine vs. prone msDWI.
STUDY TYPE: Prospective.
POPULATION: Protocol optimization: 10 healthy women (ages 22-56), supine vs. prone: 24 healthy women (ages 22-62) and five women (ages 29-61) with breast tumors.
FIELD STRENGTH/SEQUENCE: 3-T, protocol optimization msDWI: free-breathing (FB) 2-shots, FB 4-shots, respiratory-triggered (RT) 2-shots, RT 4-shots, supine vs. prone: RT 4-shot msDWI, T2-weighted fast-spin echo.
ASSESSMENT: Protocol optimization and supine vs. prone: three observers performed an image quality assessment of sharpness, aliasing, distortion (vs. T2), perceived SNR, and overall image quality (scale of 1-5). Apparent diffusion coefficients (ADCs) in fibroglandular tissue (FGT) and breast tumors were measured.
STATISTICAL TESTS: Effect of study variables on dichotomized ratings (4/5 vs. 1/2/3) and FGT ADCs were assessed with mixed-effects logistic regression. Interobserver agreement utilized Gwet's agreement coefficient (AC). Lesion ADCs were assessed by Bland-Altman analysis and concordance correlation (ρc ). P value <0.05 was considered statistically significant.
RESULTS: Protocol optimization: 4-shots significantly improved sharpness and distortion; RT significantly improved sharpness, aliasing, perceived SNR, and overall image quality. FGT ADCs were not significantly different between shots (P = 0.812), FB vs. RT (P = 0.591), or side (P = 0.574). Supine vs. prone: supine images were rated significantly higher for sharpness, aliasing, and overall image quality. FGT ADCs were significantly higher supine; lesion ADCs were highly correlated (ρc = 0.92).
DATA CONCLUSION: Based on image quality, supine msDWI outperformed prone msDWI. Lesion ADCs were highly correlated between the two positions, while FGT ADCs were higher in the supine position.
EVIDENCE LEVEL: 2.
TECHNICAL EFFICACY: Stage 1.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:58 |
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| Enthalten in: |
Journal of magnetic resonance imaging : JMRI - 58(2023), 3 vom: 13. Sept., Seite 951-962 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Moran, Catherine J [VerfasserIn] |
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| Links: |
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| Themen: |
Breast |
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| Anmerkungen: |
Date Completed 08.08.2023 Date Revised 17.08.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/jmri.28582 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 100 | 1 | |a Moran, Catherine J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Multishot Diffusion-Weighted MRI of the Breasts in the Supine vs. Prone Position |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
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| 500 | |a Date Completed 08.08.2023 | ||
| 500 | |a Date Revised 17.08.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022 International Society for Magnetic Resonance in Medicine. | ||
| 520 | |a BACKGROUND: Diffusion-weighted imaging (DWI) may allow for breast cancer screening MRI without a contrast injection. Multishot methods improve prone DWI of the breasts but face different challenges in the supine position | ||
| 520 | |a PURPOSE: To establish a multishot DWI (msDWI) protocol for supine breast MRI and to evaluate the performance of supine vs. prone msDWI | ||
| 520 | |a STUDY TYPE: Prospective | ||
| 520 | |a POPULATION: Protocol optimization: 10 healthy women (ages 22-56), supine vs. prone: 24 healthy women (ages 22-62) and five women (ages 29-61) with breast tumors | ||
| 520 | |a FIELD STRENGTH/SEQUENCE: 3-T, protocol optimization msDWI: free-breathing (FB) 2-shots, FB 4-shots, respiratory-triggered (RT) 2-shots, RT 4-shots, supine vs. prone: RT 4-shot msDWI, T2-weighted fast-spin echo | ||
| 520 | |a ASSESSMENT: Protocol optimization and supine vs. prone: three observers performed an image quality assessment of sharpness, aliasing, distortion (vs. T2), perceived SNR, and overall image quality (scale of 1-5). Apparent diffusion coefficients (ADCs) in fibroglandular tissue (FGT) and breast tumors were measured | ||
| 520 | |a STATISTICAL TESTS: Effect of study variables on dichotomized ratings (4/5 vs. 1/2/3) and FGT ADCs were assessed with mixed-effects logistic regression. Interobserver agreement utilized Gwet's agreement coefficient (AC). Lesion ADCs were assessed by Bland-Altman analysis and concordance correlation (ρc ). P value <0.05 was considered statistically significant | ||
| 520 | |a RESULTS: Protocol optimization: 4-shots significantly improved sharpness and distortion; RT significantly improved sharpness, aliasing, perceived SNR, and overall image quality. FGT ADCs were not significantly different between shots (P = 0.812), FB vs. RT (P = 0.591), or side (P = 0.574). Supine vs. prone: supine images were rated significantly higher for sharpness, aliasing, and overall image quality. FGT ADCs were significantly higher supine; lesion ADCs were highly correlated (ρc = 0.92) | ||
| 520 | |a DATA CONCLUSION: Based on image quality, supine msDWI outperformed prone msDWI. Lesion ADCs were highly correlated between the two positions, while FGT ADCs were higher in the supine position | ||
| 520 | |a EVIDENCE LEVEL: 2 | ||
| 520 | |a TECHNICAL EFFICACY: Stage 1 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a DWI | |
| 650 | 4 | |a breast | |
| 650 | 4 | |a multishot | |
| 650 | 4 | |a prone | |
| 650 | 4 | |a supine | |
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| 700 | 1 | |a Mazzoli, Valentina |e verfasserin |4 aut | |
| 700 | 1 | |a McKay-Nault, Jessica A |e verfasserin |4 aut | |
| 700 | 1 | |a Guidon, Arnaud |e verfasserin |4 aut | |
| 700 | 1 | |a Waheed, Uzma |e verfasserin |4 aut | |
| 700 | 1 | |a Rosen, Eric L |e verfasserin |4 aut | |
| 700 | 1 | |a Poplack, Steven P |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenberg, Jarrett |e verfasserin |4 aut | |
| 700 | 1 | |a Ennis, Daniel B |e verfasserin |4 aut | |
| 700 | 1 | |a Hargreaves, Brian A |e verfasserin |4 aut | |
| 700 | 1 | |a Daniel, Bruce L |e verfasserin |4 aut | |
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