The prenatal weekly temperature exposure and neonatal congenital heart disease : a large population-based observational study in China
© 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
We aim to explore the link between maternal weekly temperature exposure and CHD in offspring and identify the relative contributions from heat and cold and from moderate and extreme atmospheric temperature. From January 2019 to December 2020, newborns who were diagnosed with CHD by echocardiography in the Network Platform for Congenital Heart Disease (NPCHD) from 11 cities in eastern China were enrolled in the present study. We appraised the exposure lag response relationship between temperature and CHDs in the distributed lag nonlinear model and further probed the pooled estimates by multivariate meta-analysis. We further performed the exposure-response curves in extreme temperature (5th percentile for cold and 95th for hot events). We also delve into the cumulative risk ratios (CRRs) of temperature on CHDs in general and subgroups. In this study, 5904 of 983, 523 infants were diagnosed with CHDs. The temperature-CHD combination performed positive significance in two exposure windows, gestational weeks 10-16 and 26-31, and reached the maximum effect in the 28th week. Compared with extreme cold (5th, 6.14℃), these effects were higher in extreme heat (95th, 29.26℃). The cumulative exposure-response curve showed a steep nonlinear rise in the hot tail but showed non-significance at low temperatures. In this range, the CRRs of temperature showed an increment to a ceiling of 3.781 (95% CI: 1.460-10.723). The temperature- CHD curves for both sex groups showed a general growth trend. No statistical significance was observed between these two groups (P = 0.106). The cumulative effect of the temperature related CHD was significant in regions with lower education levels (maximum CRR was 9.282 (3.019-28.535)). A degree centigrade increase in temperature exposure was associated with the increment of CHD risk in the first and second trimesters, especially in extreme heat. Neonates born in lower education regions were more vulnerable to temperature-related CHDs.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:30 |
|---|---|
| Enthalten in: |
Environmental science and pollution research international - 30(2023), 13 vom: 31. März, Seite 38282-38291 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Xu, Weize [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Congenital heart disease |
|---|
| Anmerkungen: |
Date Completed 29.03.2023 Date Revised 28.02.2024 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s11356-022-24396-5 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM350916160 |
|---|
| LEADER | 01000caa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM350916160 | ||
| 003 | DE-627 | ||
| 005 | 20240229170011.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s11356-022-24396-5 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1310.xml |
| 035 | |a (DE-627)NLM350916160 | ||
| 035 | |a (NLM)36580248 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Xu, Weize |e verfasserin |4 aut | |
| 245 | 1 | 4 | |a The prenatal weekly temperature exposure and neonatal congenital heart disease |b a large population-based observational study in China |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 29.03.2023 | ||
| 500 | |a Date Revised 28.02.2024 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2022. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a We aim to explore the link between maternal weekly temperature exposure and CHD in offspring and identify the relative contributions from heat and cold and from moderate and extreme atmospheric temperature. From January 2019 to December 2020, newborns who were diagnosed with CHD by echocardiography in the Network Platform for Congenital Heart Disease (NPCHD) from 11 cities in eastern China were enrolled in the present study. We appraised the exposure lag response relationship between temperature and CHDs in the distributed lag nonlinear model and further probed the pooled estimates by multivariate meta-analysis. We further performed the exposure-response curves in extreme temperature (5th percentile for cold and 95th for hot events). We also delve into the cumulative risk ratios (CRRs) of temperature on CHDs in general and subgroups. In this study, 5904 of 983, 523 infants were diagnosed with CHDs. The temperature-CHD combination performed positive significance in two exposure windows, gestational weeks 10-16 and 26-31, and reached the maximum effect in the 28th week. Compared with extreme cold (5th, 6.14℃), these effects were higher in extreme heat (95th, 29.26℃). The cumulative exposure-response curve showed a steep nonlinear rise in the hot tail but showed non-significance at low temperatures. In this range, the CRRs of temperature showed an increment to a ceiling of 3.781 (95% CI: 1.460-10.723). The temperature- CHD curves for both sex groups showed a general growth trend. No statistical significance was observed between these two groups (P = 0.106). The cumulative effect of the temperature related CHD was significant in regions with lower education levels (maximum CRR was 9.282 (3.019-28.535)). A degree centigrade increase in temperature exposure was associated with the increment of CHD risk in the first and second trimesters, especially in extreme heat. Neonates born in lower education regions were more vulnerable to temperature-related CHDs | ||
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Congenital heart disease | |
| 650 | 4 | |a Distributed lag nonlinear model | |
| 650 | 4 | |a Exposure–response effect | |
| 650 | 4 | |a Multivariate meta-analysis | |
| 650 | 4 | |a Neonate | |
| 650 | 4 | |a Temperature | |
| 700 | 1 | |a Li, Die |e verfasserin |4 aut | |
| 700 | 1 | |a Shao, Zehua |e verfasserin |4 aut | |
| 700 | 1 | |a You, Yanqin |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Feixia |e verfasserin |4 aut | |
| 700 | 1 | |a Lou, Hongliang |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Yueqin |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Ting |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Lulu |e verfasserin |4 aut | |
| 700 | 1 | |a An, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Junqiu |e verfasserin |4 aut | |
| 700 | 1 | |a Cheng, Wei |e verfasserin |4 aut | |
| 700 | 1 | |a Tao, Linghua |e verfasserin |4 aut | |
| 700 | 1 | |a Lei, Yongliang |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Chengyin |e verfasserin |4 aut | |
| 700 | 1 | |a Shu, Qiang |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Environmental science and pollution research international |d 1994 |g 30(2023), 13 vom: 31. März, Seite 38282-38291 |w (DE-627)NLM093849869 |x 1614-7499 |7 nnns |
| 773 | 1 | 8 | |g volume:30 |g year:2023 |g number:13 |g day:31 |g month:03 |g pages:38282-38291 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s11356-022-24396-5 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 30 |j 2023 |e 13 |b 31 |c 03 |h 38282-38291 | ||