Design of a Patient-Specific Respiratory-Motion-Simulating Platform for In Vitro 4D Flow MRI
© 2022. The Author(s) under exclusive licence to Biomedical Engineering Society..
Four-dimensional (4D) flow magnetic resonance imaging (MRI) is a leading-edge imaging technique and has numerous medicinal applications. In vitro 4D flow MRI can offer some advantages over in vivo ones, especially in accurately controlling flow rate (gold standard), removing patient and user-specific variations, and minimizing animal testing. Here, a complete testing method and a respiratory-motion-simulating platform are proposed for in vitro validation of 4D flow MRI. A silicon phantom based on the hepatic arteries of a living pig is made. Under the free-breathing, a human volunteer's liver motion (inferior-superior direction) is tracked using a pencil-beam MRI navigator and is extracted and converted into velocity-distance pairs to program the respiratory-motion-simulating platform. With the magnitude displacement of about 1.3 cm, the difference between the motions obtained from the volunteer and our platform is ≤ 1 mm which is within the positioning error of the MRI navigator. The influence of the platform on the MRI signal-to-noise ratio can be eliminated even if the actuator is placed in the MRI room. The 4D flow measurement errors are respectively 0.4% (stationary phantom), 9.4% (gating window = 3 mm), 27.3% (gating window = 4 mm) and 33.1% (gating window = 7 mm). The vessel resolutions decreased with the increase of the gating window. The low-cost simulation system, assembled from commercially available components, is easy to be duplicated.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Annals of biomedical engineering - 51(2023), 5 vom: 29. Mai, Seite 1028-1039 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Li, Ning [VerfasserIn] |
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| Links: |
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| Themen: |
4D flow MRI |
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| Anmerkungen: |
Date Completed 25.04.2023 Date Revised 25.04.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10439-022-03117-6 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM350915911 |
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| 520 | |a Four-dimensional (4D) flow magnetic resonance imaging (MRI) is a leading-edge imaging technique and has numerous medicinal applications. In vitro 4D flow MRI can offer some advantages over in vivo ones, especially in accurately controlling flow rate (gold standard), removing patient and user-specific variations, and minimizing animal testing. Here, a complete testing method and a respiratory-motion-simulating platform are proposed for in vitro validation of 4D flow MRI. A silicon phantom based on the hepatic arteries of a living pig is made. Under the free-breathing, a human volunteer's liver motion (inferior-superior direction) is tracked using a pencil-beam MRI navigator and is extracted and converted into velocity-distance pairs to program the respiratory-motion-simulating platform. With the magnitude displacement of about 1.3 cm, the difference between the motions obtained from the volunteer and our platform is ≤ 1 mm which is within the positioning error of the MRI navigator. The influence of the platform on the MRI signal-to-noise ratio can be eliminated even if the actuator is placed in the MRI room. The 4D flow measurement errors are respectively 0.4% (stationary phantom), 9.4% (gating window = 3 mm), 27.3% (gating window = 4 mm) and 33.1% (gating window = 7 mm). The vessel resolutions decreased with the increase of the gating window. The low-cost simulation system, assembled from commercially available components, is easy to be duplicated | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 4D flow MRI | |
| 650 | 4 | |a In vitro and in vivo | |
| 650 | 4 | |a Liver motion | |
| 650 | 4 | |a Respiratory-motion-simulating platform | |
| 650 | 4 | |a Signal-to-noise ratio | |
| 700 | 1 | |a Tous, Cyril |e verfasserin |4 aut | |
| 700 | 1 | |a Dimov, Ivan P |e verfasserin |4 aut | |
| 700 | 1 | |a Fei, Phillip |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Quan |e verfasserin |4 aut | |
| 700 | 1 | |a Lessard, Simon |e verfasserin |4 aut | |
| 700 | 1 | |a Moran, Gerald |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Ning |e verfasserin |4 aut | |
| 700 | 1 | |a Kadoury, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, An |e verfasserin |4 aut | |
| 700 | 1 | |a Martel, Sylvain |e verfasserin |4 aut | |
| 700 | 1 | |a Soulez, Gilles |e verfasserin |4 aut | |
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