Association between insomnia phenotypes and subclinical myocardial injury : the Multi-Ethnic Study of Atherosclerosis
© Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society..
STUDY OBJECTIVES: To assess whether the association between insomnia and subclinical myocardial injury, as measured by cardiac troponin T (cTnT), differs across insomnia phenotypes.
METHODS: We measured cTnT in 2188 participants in the Multi-Ethnic Study of Atherosclerosis study who had completed sleep questionnaires and undergone unattended polysomnography (PSG) and 7-day actigraphy. Insomnia symptoms were defined as reporting at least one of the following ≥5 nights/week over the past 4 weeks: trouble falling asleep, waking up several times a night, having trouble getting back to sleep after waking up too early, or taking sleeping pills to help falling asleep. Obstructive sleep apnea (OSA) was defined as an apnea-hypopnea index (AHI >15 events/h). Participants were classified into insomnia phenotypes, including comorbid insomnia and OSA (COMISA) and insomnia associated with actigraphy-estimated short sleep (<6 h) or sleep fragmentation.
RESULTS: The mean age was 68.8 (SD 9.2) years, 53.6% were male. In total, 47.8% met threshold levels for insomnia symptoms, and 43.1% had an AHI >15. In adjusted linear regression models COMISA (β 0.08 [standard error (SE) 0.03], p < .01) and insomnia with short sleep duration (β 0.07 [SE 0.03], p < .05) were each associated with higher cTnT compared to a reference group with no insomnia. Insomnia with fragmented sleep (β 0.03 [SE 0.02]) was not associated with higher cTnT (p > .05) in adjusted analyses. OSA was associated with higher cTnT (β 0.09 [SE 0.03], p < .01) in adjusted models.
CONCLUSIONS: COMISA and insomnia with short sleep duration, but not insomnia symptoms alone or fragmented sleep, were associated with increased circulating cTnT in older adults.
| Errataetall: | |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Sleep - 46(2023), 4 vom: 12. Apr. |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Sigurdardottir, Fjola D [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COMISA |
|---|
| Anmerkungen: |
Date Completed 13.04.2023 Date Revised 17.04.2023 published: Print CommentIn: Sleep. 2023 Apr 12;46(4):. - PMID 36708062 Citation Status MEDLINE |
|---|
| doi: |
10.1093/sleep/zsac318 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM350910332 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM350910332 | ||
| 003 | DE-627 | ||
| 005 | 20231226050051.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231226s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/sleep/zsac318 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1169.xml |
| 035 | |a (DE-627)NLM350910332 | ||
| 035 | |a (NLM)36579654 | ||
| 035 | |a (PII)zsac318 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Sigurdardottir, Fjola D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Association between insomnia phenotypes and subclinical myocardial injury |b the Multi-Ethnic Study of Atherosclerosis |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 13.04.2023 | ||
| 500 | |a Date Revised 17.04.2023 | ||
| 500 | |a published: Print | ||
| 500 | |a CommentIn: Sleep. 2023 Apr 12;46(4):. - PMID 36708062 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Sleep Research Society 2022. Published by Oxford University Press on behalf of the Sleep Research Society. | ||
| 520 | |a STUDY OBJECTIVES: To assess whether the association between insomnia and subclinical myocardial injury, as measured by cardiac troponin T (cTnT), differs across insomnia phenotypes | ||
| 520 | |a METHODS: We measured cTnT in 2188 participants in the Multi-Ethnic Study of Atherosclerosis study who had completed sleep questionnaires and undergone unattended polysomnography (PSG) and 7-day actigraphy. Insomnia symptoms were defined as reporting at least one of the following ≥5 nights/week over the past 4 weeks: trouble falling asleep, waking up several times a night, having trouble getting back to sleep after waking up too early, or taking sleeping pills to help falling asleep. Obstructive sleep apnea (OSA) was defined as an apnea-hypopnea index (AHI >15 events/h). Participants were classified into insomnia phenotypes, including comorbid insomnia and OSA (COMISA) and insomnia associated with actigraphy-estimated short sleep (<6 h) or sleep fragmentation | ||
| 520 | |a RESULTS: The mean age was 68.8 (SD 9.2) years, 53.6% were male. In total, 47.8% met threshold levels for insomnia symptoms, and 43.1% had an AHI >15. In adjusted linear regression models COMISA (β 0.08 [standard error (SE) 0.03], p < .01) and insomnia with short sleep duration (β 0.07 [SE 0.03], p < .05) were each associated with higher cTnT compared to a reference group with no insomnia. Insomnia with fragmented sleep (β 0.03 [SE 0.02]) was not associated with higher cTnT (p > .05) in adjusted analyses. OSA was associated with higher cTnT (β 0.09 [SE 0.03], p < .01) in adjusted models | ||
| 520 | |a CONCLUSIONS: COMISA and insomnia with short sleep duration, but not insomnia symptoms alone or fragmented sleep, were associated with increased circulating cTnT in older adults | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a COMISA | |
| 650 | 4 | |a cardiac troponin | |
| 650 | 4 | |a insomnia | |
| 650 | 4 | |a subclinical myocardial injury | |
| 700 | 1 | |a Bertisch, Suzanne M |e verfasserin |4 aut | |
| 700 | 1 | |a Reid, Michelle L |e verfasserin |4 aut | |
| 700 | 1 | |a deFilippi, Christopher R |e verfasserin |4 aut | |
| 700 | 1 | |a Lima, Joao A C |e verfasserin |4 aut | |
| 700 | 1 | |a Redline, Susan |e verfasserin |4 aut | |
| 700 | 1 | |a Omland, Torbjørn |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Sleep |d 1986 |g 46(2023), 4 vom: 12. Apr. |w (DE-627)NLM00225574X |x 1550-9109 |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2023 |g number:4 |g day:12 |g month:04 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/sleep/zsac318 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2023 |e 4 |b 12 |c 04 | ||